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Digestive Diseases and Sciences

, Volume 64, Issue 1, pp 283–284 | Cite as

Preventive Effects of Epinephrine for Critically Ill Patients? More Questions Waiting to Be Answered

  • Shanlan Shi
  • Yi Lin
  • Ru Ding
  • Yihong Chen
  • Feng Wu
  • Zhiqing He
  • Zonggui WuEmail author
  • Chun LiangEmail author
Correspondence
  • 51 Downloads

To the Editors,

We read with great interest the paper about the preventive effects of epinephrine on the occurrence of stress ulcer-induced gastrointestinal bleeding in critically ill patients published recently by Becq et al. [1]. In contrary to previous findings, increase usage of epinephrine per day was shown to delay the stress ulcer occurrence among intensive care unit (ICU) patients.

However, we still have some concerns about the study. First, in addition to epinephrine, other vasopressors, such as norepinephrine and dopamine, are also widely used in such populations [2, 3], which might lead to potential bias in assessing epinephrine’s preventive effects, but no data about the associated drug usage were revealed.

Second, stress ulcer-induced gastrointestinal bleeding could be one of the remote organ consequences of acute kidney injury (AKI) or failure among ICU patients [4]. Considering that 60% of enrolled participants received renal replacement therapy, it is natural to...

Notes

Funding

This work was supported by NSFC Grants (91539118, 81611130092) to C.L., NSFC Grant (81770352) to R.D., NSFC Grant (81473445) to ZG. W., CSC (201703170134) to Y.C., Program of Shanghai Academic Research Leader (17XD1405000), Program for Outstanding Medical Academic Leader (LJRC2015-21), and Shanghai Pilot project for clinical collaboration between TCM and Western Medicine (ZY 2018-2020-FWTX-1102) to C.L.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of CardiologyShanghai Baoshan Traditional Chinese Medicine-Integrated HospitalShanghaiChina
  2. 2.Department of CardiologyFuzhou General Hospital of Nanjing Military CommandFuzhouChina
  3. 3.Department of Cardiology, Shanghai Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  4. 4.Department of Clinical Sciences MalmöLund UniversityMalmöSweden

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