New Risk Factors for Infected Pancreatic Necrosis Secondary to Severe Acute Pancreatitis: The Role of Initial Contrast-Enhanced Computed Tomography
- 71 Downloads
Background and Aims
Pancreatic necrosis is a risk factor for poor prognosis of acute pancreatitis (AP). However, the associations between the findings on initial contrast-enhanced computed tomography (CT) of the pancreas and infected pancreatic necrosis (IPN) are unclear.
This was a retrospective cohort study. Patients with severe AP (SAP) from January 2014 to December 2016 at the First Affiliated Hospital of Nanchang University were enrolled and assigned to an IPN group and a non-IPN group. Univariate and multivariate logistic regression analyses were sequentially performed to assess the associations between the variables and IPN development. A receiver operating characteristic (ROC) curve was generated for the qualified independent risk factor.
Forty-two patients with IPN were compared with 100 patients without IPN. Contrast-enhanced CT was performed 7 (range 3–10) days after AP onset. Multivariate stepwise logistic regression analyses showed that the number of acute peripancreatic fluid collections (APFCs) (OR 1.328, P = 0.006), presence of peripancreatic and pancreatic parenchymal necrosis (OR 4.001, P = 0.001), and gastrointestinal wall thickening (OR 3.353, P = 0.006) were independent risk factors for IPN secondary to SAP. The area under an ROC curve for the number of APFCs was 0.714, the sensitivity was 78.60%, and the specificity was 57.30% at a cutoff value of 4.5.
The number of APFCs, presence of peripancreatic and pancreatic parenchymal necrosis, and gastrointestinal wall thickening were independent risk factors associated with IPN. As initial contrast-enhanced CT (about 7 days from AP onset) plays an important role in predicting IPN, it is important for clinicians to consider initial imaging of the pancreas.
KeywordsPancreatitis Infection Risk factors Multidetector computed tomography
Infected pancreatic necrosis
Acute peripancreatic fluid collection
Receiver operating characteristic
This work was supported in part by grants from the National Natural Science Foundation of China (No. 81760120), the Jiangxi key Research and Development Program (No. 20171BBG70084), and the Jiangxi Graduate Special Fund for Innovative Projects (No. YC2017-S090).
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
- 21.Rotman N, Chevret S, Pezet D, et al. Prognostic value of early computed tomographic scans in severe acute pancreatitis. J Am Coll Surg. 1994;179:538–544.Google Scholar
- 22.Sternby H, Verdonk RC, Aguilar G, et al. Significant inter-observer variation in the diagnosis of extrapancreatic necrosis and type of pancreatic collections in acute pancreatitis—an international multicenter evaluation of the revised Atlanta classification. Pancreatology. 2016;16:791–797.CrossRefGoogle Scholar