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Digestive Diseases and Sciences

, Volume 64, Issue 2, pp 532–543 | Cite as

Epidemiological Trends in Gastrointestinal Cancers in China: An Ecological Study

  • Liting Xi
  • Jinzhou Zhu
  • Huixian Zhang
  • Merlin Muktiali
  • Chunfang Xu
  • Airong WuEmail author
Original Article
  • 96 Downloads

Abstract

Background

In recent decades, the patterns and trends of gastrointestinal (GI) cancer epidemics in Chinese population have been changing.

Aims

To present the epidemiological trends and geographic distributions of four major GI cancers (esophageal cancer, stomach cancer, liver cancer and colorectal cancer) in China from 2010 to 2014.

Methods

It used standardized data extracted from the National Central Cancer Registry database.

Results

The age-standardized incidence rates (ASIR) of esophageal cancer decreased from 16.7 to 12.2 per 100,000 and the age-standardized mortality rates (ASMR) decreased from 12.0 to 8.8 per 100,000. The ASIR and the ASMR of stomach cancer dropped from 23.7 to 19.5 per 100,000 and from 16.6 to 13.3 per 100,000. The ASIR of liver cancer fell from 21.4 to 17.8 per 100,000 and its ASMR fell from 18.4 per 100,000 to 15.3 per 100,000. The ASIR of colorectal cancer increased from 16.1 to 17.5 per 100,000, whereas the ASMR fluctuated between 7.6 and 7.9 per 100,000. Moreover, the incidence and mortality of each cancer differed between males and females, urban and rural residence, as well as various regions.

Conclusion

From 2010 to 2014, esophageal cancer, stomach cancer and liver cancer showed downward trend, while the ASIR of colorectal cancer slightly rose and its ASMR presented stable.

Keywords

Esophageal cancer Stomach cancer Liver cancer Colorectal cancer National Central Cancer Registry (NCCR) Epidemiology 

Notes

Acknowledgments

The work was supported by Jiangsu Provincial Key Research and Development Plan (No. BE2018659).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10620_2018_5335_MOESM1_ESM.tif (252 kb)
Fig. S1 Percentages of current tobacco smoking in China, by gender (2000–2015). Data source: WHO. WHO global report on trends in tobacco smoking 2000–2015. (TIFF 252 kb)
10620_2018_5335_MOESM2_ESM.tif (175 kb)
Fig. S2 Trends in the prevalence (%) of overweight and obesity among adults (aged ≧ 18 years old) in China (1992–2012). Data source: China National Nutrition and Health Survey (CNNHS) (1992–2012), the largest nationally representative survey in China conducted every 10 years. According to the Chinese standard, obesity was defined as BMI ≧ 28 kg/m2 and overweight was defined as 28 > BMI ≧ 24 kg/m2. (TIFF 174 kb)
10620_2018_5335_MOESM3_ESM.tif (196 kb)
Fig. S3 Changes in the food intake in Chinese daily diet (2002–2012). Data source: China National Nutrition and Health Survey (CNNHS) (1992–2012), the largest nationally representative survey in China conducted every 10 years. (TIFF 196 kb)
10620_2018_5335_MOESM4_ESM.docx (11 kb)
Supplementary material 4 (DOCX 11 kb)

References

  1. 1.
    Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018.Google Scholar
  2. 2.
    Chen W, Zheng R, Zhang S, et al. Cancer incidence and mortality in China, 2013. Cancer Lett. 2017;401:63–71.CrossRefGoogle Scholar
  3. 3.
    Chen W, Zheng R, Zhang S, Zhao P, Zeng H, Zou X. Report of cancer incidence and mortality in China, 2010. Ann Transl Med. 2014;2:61.Google Scholar
  4. 4.
    Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–132.CrossRefGoogle Scholar
  5. 5.
    Costa NR, da Costa RMG, Medeiros R. A viral map of gastrointestinal cancers. Life Sci. 2018;199:188–200.CrossRefGoogle Scholar
  6. 6.
    Prabhu A, Obi KO, Rubenstein JH. The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis. Am J Gastroenterol. 2014;109:822–827.CrossRefGoogle Scholar
  7. 7.
    Smyth EC, Lagergren J, Fitzgerald RC, et al. Oesophageal cancer. Nat Rev Dis Primers. 2017;3:17048.CrossRefGoogle Scholar
  8. 8.
    Dong J, Thrift AP. Alcohol, smoking and risk of oesophago-gastric cancer. Best Pract Res Clin Gastroenterol. 2017;31:509–517.CrossRefGoogle Scholar
  9. 9.
    Liu Z, Talukdar FR, Ghosh SK, Laskar RS, Mondal R. Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India. PLoS One. 2013;8:e60996.CrossRefGoogle Scholar
  10. 10.
    Lima SCS, Hernández-Vargas H, Simão T, et al. Identification of a DNA methylome signature of esophageal squamous cell carcinoma and potential epigenetic biomarkers. Epigenetics. 2014;6:1217–1227.CrossRefGoogle Scholar
  11. 11.
    Mani S, Szymańska K, Cuenin C, et al. DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract. Epigenetics. 2014;7:270–277.CrossRefGoogle Scholar
  12. 12.
    Islami F, Ren JS, Taylor PR, Kamangar F. Pickled vegetables and the risk of oesophageal cancer: a meta-analysis. Br J Cancer. 2009;101:1641–1647.CrossRefGoogle Scholar
  13. 13.
    Yang CS. Research on esophageal cancer in China: a review. Cancer Res. 1980;40:2633–2644.Google Scholar
  14. 14.
    Lagergren J, Lagergren P. Recent developments in esophageal adenocarcinoma. CA Cancer J Clin. 2013;63:232–248.CrossRefGoogle Scholar
  15. 15.
    Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003–15: a pooled analysis of 17 population-based cancer registries. Lancet Global Health. 2018;6:e555–e567.CrossRefGoogle Scholar
  16. 16.
    Chen W, Zeng H, Chen R, et al. Evaluating efficacy of screening for upper gastrointestinal cancer in China: a study protocol for a randomized controlled trial. Chin J Cancer Res. 2017;29:294–302.CrossRefGoogle Scholar
  17. 17.
    Zou XN. Epidemic trend, screening, and early detection and treatment of cancer in Chinese population. Cancer Biol Med. 2017;14:50–59.CrossRefGoogle Scholar
  18. 18.
    Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014. Chin J Cancer Res. 2018;30:1–12.CrossRefGoogle Scholar
  19. 19.
    Tian D, Mo S-J, Han L-K, et al. Investigation of dietary factors and esophageal cancer knowledge: comparison of rural residents in high- and low-incidence areas. Sci Rep. 2018;8:4914.CrossRefGoogle Scholar
  20. 20.
    Cheung KS, Leung WK. Risk of gastric cancer development after eradication of Helicobacter pylori. World J Gastrointest Oncol. 2018;10:115–123.CrossRefGoogle Scholar
  21. 21.
    Buckland G, Travier N, Huerta JM, et al. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study. Int J Cancer. 2015;137:598–606.CrossRefGoogle Scholar
  22. 22.
    Leung WK, Wu M-S, Kakugawa Y, et al. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008;9:279–287.CrossRefGoogle Scholar
  23. 23.
    Yao X-Q, Chen X-Z, Huang C-Z, Hu W-X, Liu Y. Gastric cancer screening by combined determination of serum helicobacter pylori antibody and pepsinogen concentrations: ABC method for gastric cancer screening. Chin Med J. 2018;131:1232.CrossRefGoogle Scholar
  24. 24.
    Wang F, Meng W, Wang B, Qiao L. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett. 2014;345:196–202.CrossRefGoogle Scholar
  25. 25.
    Sitarz R, Skierucha M, Mielko J, Offerhaus J, Maciejewski R, Polkowski W. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239–248.CrossRefGoogle Scholar
  26. 26.
    Shen L, Shan Y-S, Hu H-M, et al. Management of gastric cancer in Asia: resource-stratified guidelines. Lancet Oncol. 2013;14:e535–e547.CrossRefGoogle Scholar
  27. 27.
    Long B, Yu Z-Y, Li Q, et al. A systematic review and network meta-analysis protocol of neoadjuvant treatments for patients with gastric cancer. Medicine. 2018;97:e0392.CrossRefGoogle Scholar
  28. 28.
    Fu J, Wang H. Precision diagnosis and treatment of liver cancer in China. Cancer Lett. 2018;412:283–288.CrossRefGoogle Scholar
  29. 29.
    Chen JG, Zhang SW. Liver cancer epidemic in China: past, present and future. Semin Cancer Biol. 2011;21:59–69.CrossRefGoogle Scholar
  30. 30.
    Liang X, Bi S, Yang W, et al. Epidemiological serosurvey of Hepatitis B in China: declining HBV prevalence due to Hepatitis B vaccination. Vaccine. 2009;27:6550–6557.CrossRefGoogle Scholar
  31. 31.
    Zu J, Zhuang G, Liang P, et al. Estimating age-related incidence of HBsAg seroclearance in chronic hepatitis B virus infections of China by using a dynamic compartmental model. Sci Rep. 2017;7:2912.CrossRefGoogle Scholar
  32. 32.
    Tsochatzis EA, Meyer T, Burroughs AK. Hepatocellular carcinoma. N Engl J Med. 2012;83:693.Google Scholar
  33. 33.
    Chen JG, Lu JH, Zhang YH, Wang JB, Zhu J, Zhu YR. Progress and application of alpha-fetoprotin for screening. China Cancer. 2009;18:609–612.Google Scholar
  34. 34.
    Liu W, Liu Q, Huang Q, et al. Time trend analysis of primary liver cancer incidence in Sihui county of Guangdong Province, China (1987–2011). BMC Cancer. 2016;16:796.CrossRefGoogle Scholar
  35. 35.
    Shin A. Colorectal cancer mortality in Hong Kong of China, Japan, South Korea, and Singapore. World J Gastroenterol. 2013;19:979.CrossRefGoogle Scholar
  36. 36.
    Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67:177–193.CrossRefGoogle Scholar
  37. 37.
    Strum WB, Longo DL. Colorectal adenomas. N Engl J Med. 2016;374:1065–1075.CrossRefGoogle Scholar
  38. 38.
    Corley DA, Jensen CD, Marks AR, et al. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014;370:2539–2540.CrossRefGoogle Scholar
  39. 39.
    Kerr J, Anderson C, Lippman SM. Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. Lancet Oncol. 2017;18:e457–e471.CrossRefGoogle Scholar
  40. 40.
    Schreuders EH, Ruco A, Rabeneck L, et al. Colorectal cancer screening: a global overview of existing programmes. Gut. 2015;64:1637–1649.CrossRefGoogle Scholar
  41. 41.
    Deng SX, Gao J, An W, et al. Colorectal cancer screening behavior and willingness: an outpatient survey in China. World J Gastroenterol. 2011;17:3133–3139.Google Scholar
  42. 42.
    Gong Y, Peng P, Bao P, et al. The implementation and first-round results of a community-based colorectal cancer screening program in Shanghai, China. Oncologist. 2018;23:928–935.CrossRefGoogle Scholar
  43. 43.
    Zhu J, Tan Z, Hollis-Hansen K, Zhang Y, Yu C, Li Y. Epidemiological trends in colorectal cancer in China: an ecological study. Dig Dis Sci. 2016;62:235–243.  https://doi.org/10.1007/s10620-016-4362-4 CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Liting Xi
    • 1
  • Jinzhou Zhu
    • 1
  • Huixian Zhang
    • 1
  • Merlin Muktiali
    • 2
  • Chunfang Xu
    • 1
  • Airong Wu
    • 1
    Email author
  1. 1.Department of GastroenterologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina
  2. 2.Department of OncologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina

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