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Digestive Diseases and Sciences

, Volume 63, Issue 12, pp 3425–3433 | Cite as

Cyclic Change of Sphincter of Oddi Motility and Its Relationship with Small Bowel Migrating Motor Complex in Humans

  • Byung Moo Yoo
  • Jin Hong KimEmail author
  • Min Jae Yang
  • Glen A. Lehman
  • Jae Chul Hwang
  • Soon Sun Kim
  • Joon Koo Kang
  • Sun Gyo Lim
  • Sung Jae Shin
  • Jae Youn Cheong
  • Kee Myung Lee
Original Article
  • 116 Downloads

Abstract

Background

Several animal and human studies have reported that sphincter of Oddi (SO) motility shows cyclical changes during the fasting state. However, to date, the relationship between the SO motility and the migrating motor complex (MMC) of the small bowel (SB) remains unclear in humans.

Aims

We observed SO motility over a long study period and evaluated its relationship with the MMC of the SB in humans using percutaneous long-term manometry.

Methods

Our study included patients with hepatolithiasis who required percutaneous transhepatic catheter placement and subsequently underwent choledochoscopy and stone removal. Long-term percutaneous transhepatic SO manometry was performed after complete stone removal. SO and SB motility were simultaneously recorded.

Results

SO motility showed cyclical phasic changes with periodic high-frequency contractions similar to the MMC contractions of the SB. All high-frequency contractions of the SO coincided with phase III contractions of the MMC of the SB. The proportions of phase III contractions of SO and SB were similar, but the proportions of phase I (P = 0.001) and phase II (P = 0.002) contractions were significantly different. The mean basal SO pressure was observed to significantly increase in phase III compared to phase I (P = 0.001) and phase II (P = 0.001) contractions.

Conclusions

SO motility in humans showed cyclical phasic changes closely coordinated with the MMC of the SB in a fasting state; however, the proportion of phases differed between the SO and the SB. The basal pressure significantly increased during physiological high-frequency phase III contractions of the SO.

Keywords

Sphincter of Oddi Small intestine Migrating motor complex Gastrointestinal motility 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Byung Moo Yoo
    • 1
  • Jin Hong Kim
    • 1
    Email author
  • Min Jae Yang
    • 1
  • Glen A. Lehman
    • 2
  • Jae Chul Hwang
    • 1
  • Soon Sun Kim
    • 1
  • Joon Koo Kang
    • 1
  • Sun Gyo Lim
    • 1
  • Sung Jae Shin
    • 1
  • Jae Youn Cheong
    • 1
  • Kee Myung Lee
    • 1
  1. 1.Department of GastroenterologyAjou University School of MedicineSuwon-siSouth Korea
  2. 2.Division of Gastroenterology and HepatologyIndiana University School of MedicineIndianapolisUSA

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