Digestive Diseases and Sciences

, Volume 63, Issue 11, pp 2959–2968 | Cite as

Expression of DDB2 Protein in the Initiation, Progression, and Prognosis of Colorectal Cancer

  • Huaiwei Yang
  • Jingwei Liu
  • Jingjing Jing
  • Zeyang Wang
  • Yi Li
  • Kaihua Gou
  • Xue Feng
  • Yuan YuanEmail author
  • Chengzhong XingEmail author
Original Article



Damage-specific DNA binding protein 2 (DDB2) is implicated in the recognition of DNA damage and the initiation of nucleotide excision repair process. The aim of this study was to explore the role of DDB2 in the initiation, progression, and prognosis of colorectal cancer (CRC).


Totally tissues of 300 CRC and 300 adjacent, 267 colorectal adenoma (CRA) and 214 normal (NOR) were collected. The expression of DDB2 protein was detected by immunohistochemical staining.


DDB2 protein was highly expressed in CRC and CRA compared with NOR (P < 0.001, respectively) in the dynamic sequence of NOR → CRA → CRC; CRC tissue demonstrated increased DDB2 expression compared with non-tumor adjacent tissues (P < 0.001). DDB2 expression was higher in T1–T2 than that in T3–T4 in CRC (P = 0.023); cloddy/nested CRC demonstrated increased DDB2 expression than infiltrative CRC (P = 0.007). Survival analysis showed that high DDB2 expression was associated with favorable survival in colon cancer (adjusted HR 0.20, 95% CI 0.06–0.72, P = 0.014) and female CRC patients (adjusted HR 0.27, 95% CI 0.08–0.92, P = 0.036).


DDB2 protein expression was associated with the initiation, progression, and prognosis of CRC, and might function as a tumor biomarker for the diagnosis and prognosis of CRC.


DDB2 Expression Colorectal cancer 



This study is supported by grants from Public Welfare Foundation of Liaoning Province (No. 2015005002) and Fund for Scientific Research of The First Hospital of China Medical University (FHCMU-FSR).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Supplementary material

10620_2018_5224_MOESM1_ESM.docx (18 kb)
Supplementary material 1 (DOCX 17 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Tumor Etiology and Screening Department of Cancer Institute and General SurgeryThe First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education DepartmentShenyang CityChina

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