Alterations in Polyunsaturated Fatty Acid Metabolism and Reduced Serum Eicosadienoic Acid Level in Ulcerative Colitis: Is There a Place for Metabolomic Fatty Acid Biomarkers in IBD?
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To the Editors,
We read with great interest the article by Nishiumi et al. , which reported altered levels of some metabolites, including polyunsaturated fatty acids (PUFAs) and lipid mediators, and high colonic and plasma levels of docosahexaenoic acid (DHA), in IL-10 knockout mice. This and some earlier studies have shown that alterations in serum/plasma levels of ω-6 and ω-3 PUFAs seem to be associated with inflammatory bowel diseases (IBD). In particular, PUFA levels show correlations with proinflammatory cytokines deeply involved in the pathogenesis of IBD [2, 3].
Recently, we also performed a pilot comparative metabolomic study among patients with mild-to-moderate active ulcerative colitis (UC; n = 40) and healthy controls (HCs; n = 42) with an emphasis on the determination of serum free fatty acids by using gas chromatography/mass spectrometry . We identified significant changes in the serum metabolome of UC patients, reflecting pathway disturbances in glycolysis, the...
All authors drafted and critically revised the manuscript, and approved the final version.
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Conflict of interest
The authors declare that they have no conflict of interest.
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