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Digestive Diseases and Sciences

, Volume 63, Issue 10, pp 2703–2713 | Cite as

Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA

  • Peiqi Wang
  • Jun Hu
  • Shadi Ghadermarzi
  • Ali Raza
  • Douglas O’Connell
  • Amy Xiao
  • Faraz Ayyaz
  • Min Zhi
  • Yuanqi Zhang
  • Nimisha K. Parekh
  • Mark Lazarev
  • Alyssa Parian
  • Steven R. Brant
  • Marshall Bedine
  • Brindusa Truta
  • Pinjin Hu
  • Rupa Banerjee
  • Susan M. Hutfless
Original Article
  • 174 Downloads

Abstract

Background

Cigarette smoking is thought to increase the risk of Crohn’s disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia.

Aims

We aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes.

Methods

We recruited IBD cases and controls between 2014 and 2018. All participants completed a questionnaire about demographic characteristics, environmental risk factors and IBD history.

Results

We recruited 337 participants from China, 194 from India, and 645 from the USA. In China, CD cases were less likely than controls to be current smokers (adjusted odds ratio [95% CI] 0.4 [0.2–0.9]). There was no association between current or former smoking and CD in the USA. In China and the USA, UC cases were more likely to be former smokers than controls (China 14.6 [3.3–64.8]; USA 1.8 [1.0–3.3]). In India, both CD and UC had similar current smoking status to controls at diagnosis. Current smoking at diagnosis was significantly associated with greater use of immunosuppressants (4.4 [1.1–18.1]) in CD cases in China.

Conclusions

We found heterogeneity in the associations of smoking and IBD risk and outcomes between China, India, and the USA. Further study with more adequate sample size and more uniform definition of smoking status is warranted.

Keywords

Smoking Crohn’s disease Ulcerative colitis Asia Environment 

Notes

Acknowledgments

We acknowledge ResearchMatch.org. Part of the recruitment for the study included was done via ResearchMatch, a national health volunteer registry that was created by several academic institutions and supported by the United States National Institutes of Health as part of the Clinical Translational Science Award (CTSA) program. ResearchMatch has a large population of volunteers who have consented to be contacted by researchers about health studies for which they may be eligible. We also acknowledge Girish Ganesh and Kavitha Medaboina for their help in recruiting participants at Asian Institute of Gastroenterology in Hyderabad, India. We acknowledge the grant support from Sun Yat-sen University Clinical Research 5010 Program (2014008), Ludwig-Bayless Science Award, and the Johns Hopkins Institute for Clinical and Translational Research (ICTR) which is funded in part by Grant Number UL1 TR 001079 from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. The contents are solely the responsibility of the authors and do not necessarily represent the official view of the Johns Hopkins ICTR, NCATS, or NIH.

Compliance with ethical standards

Conflict of interest

No authors have conflict of interest with relation to this study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Peiqi Wang
    • 1
  • Jun Hu
    • 2
    • 3
  • Shadi Ghadermarzi
    • 4
  • Ali Raza
    • 5
  • Douglas O’Connell
    • 6
  • Amy Xiao
    • 7
  • Faraz Ayyaz
    • 8
  • Min Zhi
    • 2
  • Yuanqi Zhang
    • 2
  • Nimisha K. Parekh
    • 6
  • Mark Lazarev
    • 9
  • Alyssa Parian
    • 9
  • Steven R. Brant
    • 10
  • Marshall Bedine
    • 9
  • Brindusa Truta
    • 9
  • Pinjin Hu
    • 2
  • Rupa Banerjee
    • 11
  • Susan M. Hutfless
    • 12
    • 13
  1. 1.Department of SurgeryJohns Hopkins UniversityBaltimoreUSA
  2. 2.Department of GastroenterologyThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina
  3. 3.Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalGuangzhouChina
  4. 4.Department of Internal MedicineEast Carolina UniversityGreenvilleUSA
  5. 5.Department of Cardiology, Boston Children’s HospitalHarvard Medical SchoolBostonUSA
  6. 6.School of Medicine, Division of GastroenterologyUniversity of CaliforniaIrvineUSA
  7. 7.Department of Biomedical Engineering, Whiting School of EngineeringJohns Hopkins UniversityBaltimoreUSA
  8. 8.Services Institute of Medical SciencesLahorePakistan
  9. 9.Department of Medicine, Division of Gastroenterology and Hepatology, Meyerhoff Inflammatory Bowel Disease CenterJohns Hopkins UniversityBaltimoreUSA
  10. 10.Department of Medicine, Division of Gastroenterology and Hepatology, Rutgers HealthRobert Wood Johnson Medical SchoolNew BrunswickUSA
  11. 11.Asian Institute of GastroenterologyHyderabadIndia
  12. 12.Division of Gastroenterology and Hepatology, Gastrointestinal Epidemiology Research CenterJohns Hopkins UniversityBaltimoreUSA
  13. 13.Department of EpidemiologyJohns Hopkins University Bloomberg School of Public HealthBaltimoreUSA

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