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Digestive Diseases and Sciences

, Volume 62, Issue 8, pp 2102–2112 | Cite as

Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea, 2011–2014: A Nationwide Population-Based Study

  • Yoon Suk Jung
  • Minkyung Han
  • Won Ho Kim
  • Sohee ParkEmail author
  • Jae Hee CheonEmail author
Original Article

Abstract

Background

The incidence of inflammatory bowel disease (IBD) is increasing in East Asia; however, population-based data from this region are lacking.

Aim

We conducted a nationwide, population-based study to examine the incidence and disease course of IBD in South Korea.

Methods

Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD [10,049 with ulcerative colitis (UC) and 5595 with Crohn’s disease (CD)] from 2011 to 2014.

Results

During the study period, the average annual incidence of UC was 5.0 per 105, while that of CD was 2.8 per 105. Among patients with UC, the cumulative rates of surgery 1 and 4 years after diagnosis were 1.0 and 2.0%; those among patients with CD were 9.0 and 13.9%, respectively. The 1- and 4-year cumulative rates of moderate- to high-dose corticosteroid use were, respectively, 26.6 and 45.2% among patients with UC, and 29.9 and 50.8% among those with CD. Similarly, the 1- and 4-year cumulative rates of immunomodulator use were 14.1 and 26.4% among patients with UC, and 58.3 and 76.1% among those with CD, respectively. With regard to biologic use, the 1- and 4-year cumulative rates were 3.0 and 9.0% among patients with UC, and 11.1 and 31.7% among those with CD, respectively.

Conclusions

The recent incidence of IBD in South Korea has been the highest in East Asia. Patients who had been diagnosed recently with IBD showed lower rates of surgery and higher rates of immunomodulator and biologic use compared to those reported ever in South Korea.

Keywords

Ulcerative colitis Crohn’s disease Incidence Clinical course South Korea 

Notes

Acknowledgments

This research was supported by two Grants (A120176 and HI13C1345) from the Korean Health Technology R&D Project of the Korean Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health and Welfare of the Republic of Korea. We also received two Grants (NRF-2013R1A2A2A01067123 and NRF-2014R1A1A1008096) from the Basic Science Research Program of the National Research Foundation of Korea, which is funded by the Ministry of Science, ICT, and Future Planning. Finally we were provided with a Faculty Research Grant (2012-31-0477) from the Department of Internal Medicine, Yonsei University College of Medicine.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict to interest.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulRepublic of Korea
  2. 2.Department of Public Health, Graduate SchoolYonsei UniversitySeoulRepublic of Korea
  3. 3.Department of Internal Medicine and Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea
  4. 4.Department of Biostatistics, Graduate School of Public HealthYonsei UniversitySeoulRepublic of Korea

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