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Digestive Diseases and Sciences

, Volume 62, Issue 7, pp 1745–1750 | Cite as

Complications of Chronic Pancreatitis

  • Mitchell L. Ramsey
  • Darwin L. Conwell
  • Phil A. HartEmail author
Review

Abstract

Chronic pancreatitis is a disease that leads to irreversible changes in the pancreatic morphology and function. The loss of function can lead to diabetes mellitus and exocrine pancreatic insufficiency. The inflammation and fibrosis can also lead to other complications including a chronic abdominal pain syndrome, metabolic bone disease, and pancretic cancer. This article reviews our current understanding of the mechanisms and management of these complications of chronic pancreatitis.

Keywords

Type 3c diabetes mellitus Pancreatogenic diabetes Pancreatic pseudocyst Pancreatic cancer Splenic vein thrombus 

Abbreviations

BMD

Bone mineral density

CP

Chronic pancreatitis

CCK

Cholecystokinin

EPI

Exocrine pancreatic insufficiency

PDAC

Pancreatic ductal adenocarcinoma

PERT

Pancreatic enzyme replacement therapy

DM

Diabetes mellitus

T3cDM

Type 3c diabetes mellitus

PFT

Pancreatic function testing

TZD

Thiazolidinediones

GLP-1

Glucagon-like peptide-1

GIP

Glucose-dependent insulinotropic polypeptide

SVT

Splenic vein thrombosis

Notes

Acknowledgments

Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes And Digestive and Kidney Diseases (NIDDK) under Award Number U01DK108327 (PH, DC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Compliance with ethical standards

Conflict of interest

Hart (Abbvie, Inc., honorarium for speaking and KC Specialty Therapeutics, LLC, consulting fees).

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Mitchell L. Ramsey
    • 1
  • Darwin L. Conwell
    • 1
  • Phil A. Hart
    • 1
    Email author
  1. 1.Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and NutritionThe Ohio State University Wexner Medical CenterColumbusUSA

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