Digestive Diseases and Sciences

, Volume 62, Issue 7, pp 1745–1750 | Cite as

Complications of Chronic Pancreatitis

  • Mitchell L. Ramsey
  • Darwin L. Conwell
  • Phil A. HartEmail author


Chronic pancreatitis is a disease that leads to irreversible changes in the pancreatic morphology and function. The loss of function can lead to diabetes mellitus and exocrine pancreatic insufficiency. The inflammation and fibrosis can also lead to other complications including a chronic abdominal pain syndrome, metabolic bone disease, and pancretic cancer. This article reviews our current understanding of the mechanisms and management of these complications of chronic pancreatitis.


Type 3c diabetes mellitus Pancreatogenic diabetes Pancreatic pseudocyst Pancreatic cancer Splenic vein thrombus 



Bone mineral density


Chronic pancreatitis




Exocrine pancreatic insufficiency


Pancreatic ductal adenocarcinoma


Pancreatic enzyme replacement therapy


Diabetes mellitus


Type 3c diabetes mellitus


Pancreatic function testing




Glucagon-like peptide-1


Glucose-dependent insulinotropic polypeptide


Splenic vein thrombosis



Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes And Digestive and Kidney Diseases (NIDDK) under Award Number U01DK108327 (PH, DC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Compliance with ethical standards

Conflict of interest

Hart (Abbvie, Inc., honorarium for speaking and KC Specialty Therapeutics, LLC, consulting fees).


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Mitchell L. Ramsey
    • 1
  • Darwin L. Conwell
    • 1
  • Phil A. Hart
    • 1
    Email author
  1. 1.Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and NutritionThe Ohio State University Wexner Medical CenterColumbusUSA

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