Digestive Diseases and Sciences

, Volume 62, Issue 4, pp 913–921 | Cite as

The Efficacy of a Novel Tissue Grasper-Clips Technique for Large Perforations of the Sigmoid Colon in an Experimental Animal Model (Video)

  • Jun Young Eun
  • Yunho JungEmail author
  • Tae Hoon Lee
  • Young Sin Cho
  • Ho Sung Rhee
  • Young Kyu Jung
  • Joung-Ho Han
  • Duk Su Kim
  • Il Kwun Chung
  • Sang-Heum Park
  • Sun Joo Kim
Original Article



The incidence of iatrogenic colonic perforation has been gradually increasing. In particular, sigmoid colon perforations are difficult to handle because of excess mobility.


The aim of this study was to evaluate the efficacy of the twin grasper-clips technique for large perforations of the sigmoid colon.


This study was designed as a prospective, randomized, experimental study using ex vivo porcine colorectal specimens. Thirty standardized and variable artificial perforations were closed in the hemoclip group (hemoclips) and twin grasper group (hemoclips with a novel tissue grasper). We counted the number of hemoclips used per case to assess the cost and efficacy of the procedure.


In the hemoclip group (n = 15), among the 20-, 25-, and 30-mm defects, the mean number of clips (4.8 ± 0.8, 6.0 ± 1.6, and 8.4 ± 2.1, respectively, p = 0.011) and closure time (7.6 ± 0.5, 9.9 ± 3.3, and 13.9 ± 4.1 min, respectively, p = 0.020) differed significantly. In the twin grasper group (n = 15), among the 20-, 25-, and 30-mm defects, the mean number of clips (4.0 ± 1.0, 5.0 ± 0.7, and 5.4 ± 1.1, respectively, p = 0.101) and closure time (7.7 ± 0.6, 8.3 ± 1.9, and 9.1 ± 2.7 min, respectively, p = 0.506) did not differ significantly. In 30-mm defects, the mean number of hemoclips used per case and total closure time were significantly lower in the twin grasper group than the hemoclip group.


The twin grasper-clips technique seems to reduce the use of hemoclips and to result in more effective and rapid closure than does the conventional technique in large perforations of the ex vivo porcine sigmoid colon.


Perforation Sigmoid colon Ex vivo 



This work was supported by the Soonchunhyang University Research Fund.

Compliance with ethical standards

Conflict of interest


Supplementary material

Supplementary material 1 (WMV 24107 kb)


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Jun Young Eun
    • 1
  • Yunho Jung
    • 1
    Email author
  • Tae Hoon Lee
    • 1
  • Young Sin Cho
    • 1
  • Ho Sung Rhee
    • 1
  • Young Kyu Jung
    • 1
  • Joung-Ho Han
    • 2
  • Duk Su Kim
    • 1
  • Il Kwun Chung
    • 1
  • Sang-Heum Park
    • 1
  • Sun Joo Kim
    • 1
  1. 1.Division of Gastroenterology, Department of MedicineSoonchunhyang University College of MedicineCheonan-siSouth Korea
  2. 2.Department of Internal MedicineChungbuk National University College of MedicineCheongjuSouth Korea

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