Digestive Diseases and Sciences

, Volume 62, Issue 4, pp 1043–1050 | Cite as

Value of Raw Rhubarb Solution in the Precaution of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis in Patients with High-Risk Factors: A Predictive Random Compared Research in One Center

  • Chong Wang
  • Qirui Li
  • Peng Ye
  • Sheng Zeng
  • Guo-Hua LiEmail author
  • You-Xiang Chen
  • Xiao-Jiang Zhou
  • Nong-Hua LvEmail author
Original Article


Background and aims

Post-ERCP pancreatitis and hyperamylasemia are common complications of endoscopic retrograde cholangiopancreatography (ERCP), especially in high-risk patients. The aim of this study is to evaluate whether a raw rhubarb solution can reduce the incidence of PEP and post-ERCP hyperamylasemia.


From October 2012 to October 2013, 2100 patients received ERCP in our Endoscopic Center. Five hundred patients with high-risk factors were enrolled randomly into the raw rhubarb group (RG, 250 cases drank a raw rhubarb soak solution per 3 h until defecation after ERCP) and the control group (CG, 250 cases drank water after ERCP) in the study. The serum amylase concentration was measured. The abdominal pain, purge time and symptoms of patients were observed in the two groups.


There were no differences in patient demographics, medical history, ERCP procedure, and patient- and procedure-related high-risk factors between the two groups. PEP incidence was 2% (5/250) in the RG group, which was lower than that in the CG group (7.6%, 19/250) (P < 0.01). The rate of post-ERCP hyperamylasemia was 5.2% (13/250) and 16.8% (42/250) in the RG group and CG group, respectively. The incidence of hyperamylasemia in the RG group was significantly lower than that in the CG group (P < 0.01). The incidence of abdominal pain 24 h after ERCP in the RG group was lower than that in the CG group (P < 0.01). No side effects were observed for raw rhubarb solution.


A raw rhubarb solution is safe and effective in preventing the incidence of PEP and hyperamylasemia in high-risk patients.


Raw rhubarb Post-ERCP pancreatitis (PEP) Hyperamylasemia Endoscopic retrograde cholangiopancreatography (ERCP) 



Post-ERCP pancreatitis


Endoscopic retrograde cholangiopancreatography


Raw rhubarb group


Control group


Acute pancreatitis


Sphincter of Oddi dysfunction


Nonsteroidal anti-inflammatory drugs


The International Clinical Trials Registry Platform from the World Health Organization


Computed tomography


White blood cell count


Alanine aminotransferase


Total bilirubin








Endoscopic naso-biliary drainage


Endoscopic papillary balloon dilatation


Bile duct




Stromal cell-derived factor-1


Toll-like receptors


Sarcoplasmic reticulum Ca2+-adenosinetriphosphatase


Standard deviation


Analysis of variance



The study was supported by the Public Health Office of Jiangxi Province of China (grant no. 20155161) and the First Affiliated Hospital of Nanchang University.

Compliance with ethical standards

Conflicts of interest

The authors have no conflicts of interest to disclose.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Chong Wang
    • 1
  • Qirui Li
    • 2
  • Peng Ye
    • 3
  • Sheng Zeng
    • 1
  • Guo-Hua Li
    • 1
    Email author
  • You-Xiang Chen
    • 1
  • Xiao-Jiang Zhou
    • 1
  • Nong-Hua Lv
    • 1
    Email author
  1. 1.Department of GastroenterologyThe First Affiliated Hospital of Nanchang UniversityNanchangChina
  2. 2.Medical College of Nanchang UniversityNanchangChina
  3. 3.Department of GastroenterologyThe People Hospital of Ganzhou CityGanzhouChina

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