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Digestive Diseases and Sciences

, Volume 62, Issue 3, pp 730–738 | Cite as

Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

  • Yoshiyasu Kono
  • Minoru Matsubara
  • Tatsuya Toyokawa
  • Ryuta Takenaka
  • Seiyu Suzuki
  • Junichirou Nasu
  • Masao Yoshioka
  • Masahiro Nakagawa
  • Motowo Mizuno
  • Hiroyuki Sakae
  • Makoto Abe
  • Tatsuhiro Gotoda
  • Ko Miura
  • Hiromitsu Kanzaki
  • Masaya Iwamuro
  • Keisuke Hori
  • Takao Tsuzuki
  • Masahide Kita
  • Seiji Kawano
  • Yoshiro Kawahara
  • Hiroyuki Okada
Original Article

Abstract

Background

The Japan Gastroenterological Endoscopy Society updated its guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment in July 2012. However, the safety of endoscopic procedures in antithrombotic drug users has not been fully investigated.

Aims

To evaluate the safety of upper gastrointestinal endoscopic procedures in antithrombotic drug users.

Methods

From September 2013 to September 2015, patients who were taking antithrombotic drugs and who underwent upper gastrointestinal endoscopic procedures were prospectively enrolled at five hospitals. Incidences of bleeding and thrombosis during endoscopic procedures were evaluated.

Results

A total of 270 patients [221 for endoscopic mucosal biopsy and 49 for endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD) were enrolled. The bleeding rate was 0.9% for endoscopic mucosal biopsy and 22% for EMR/ESD, respectively. The bleeding rate after endoscopic mucosal biopsy was not significantly high, even if antithrombotic drugs were continued (0 vs. 1%, P > 0.99), while it was significantly higher among multiple antithrombotic drug users than single drug users (5.9 vs. 0%, P < 0.05). The bleeding rate after EMR/ESD was also higher among multiple antithrombotic drug users than single drug users, but was not significantly different (33 vs. 14%, P = 0.17). Moreover, there were no differences in bleeding rates according to the cessation or continuance of antithrombotic drugs (20 vs. 25%, P = 0.74). There were no thromboembolisms in all cases.

Conclusions

Upper gastrointestinal endoscopic procedures performed under the new guidelines appear acceptable. However, endoscopic procedures among multiple antithrombotic drug users show a greater potential for bleeding.

Keywords

Antithrombotic drug Endoscopy Guidelines Hemorrhage Thromboembolism 

Notes

Acknowledgments

We are grateful to Mayumi Tokumitsu for the management of data from each hospital.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Yoshiyasu Kono
    • 1
  • Minoru Matsubara
    • 2
  • Tatsuya Toyokawa
    • 3
  • Ryuta Takenaka
    • 4
  • Seiyu Suzuki
    • 2
  • Junichirou Nasu
    • 5
  • Masao Yoshioka
    • 5
  • Masahiro Nakagawa
    • 6
  • Motowo Mizuno
    • 6
    • 7
  • Hiroyuki Sakae
    • 1
  • Makoto Abe
    • 1
  • Tatsuhiro Gotoda
    • 1
  • Ko Miura
    • 1
  • Hiromitsu Kanzaki
    • 1
  • Masaya Iwamuro
    • 1
  • Keisuke Hori
    • 1
  • Takao Tsuzuki
    • 8
  • Masahide Kita
    • 9
  • Seiji Kawano
    • 1
  • Yoshiro Kawahara
    • 10
  • Hiroyuki Okada
    • 1
  1. 1.Department of Gastroenterology and HepatologyOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan
  2. 2.Department of Internal MedicineSumitomo Bessi HospitalNiihamaJapan
  3. 3.Department of GastroenterologyNational Hospital Organization, Fukuyama Medical CenterFukuyamaJapan
  4. 4.Department of GastroenterologyTsuyama Chuo HospitalTsuyamaJapan
  5. 5.Department of Internal MedicineOkayama Saiseikai General HospitalOkayamaJapan
  6. 6.Department of Internal MedicineHiroshima City HospitalHiroshimaJapan
  7. 7.Department of Internal MedicineKurashiki Central HospitalKurashikiJapan
  8. 8.Department of Internal MedicineJapanese Red Cross Society Himeji HospitalHimejiJapan
  9. 9.Department of Internal MedicineOkayama City HospitalOkayamaJapan
  10. 10.Department of EndoscopyOkayama University HospitalOkayamaJapan

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