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Digestive Diseases and Sciences

, Volume 61, Issue 12, pp 3530–3536 | Cite as

Age and Prevalence of Esophageal Reflux Disease in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study

  • Yoshio Ikeda
  • Shinya FurukawaEmail author
  • Takenori Sakai
  • Tetsuji Niiya
  • Hiroaki Miyaoka
  • Teruki Miyake
  • Shin Yamamoto
  • Hidenori Senba
  • Yasunori Yamamoto
  • Eiji Arimitsu
  • Sen Yagi
  • Hiroki Utsunomiya
  • Keiko Tanaka
  • Eiji Takeshita
  • Bunzo Matsuura
  • Yoshihiro Miyake
  • Yoichi Hiasa
Original Article

Abstract

Background

Only limited epidemiological evidence exists regarding the relationship between age and gastroesophageal reflux disease (GERD) among Japanese patients with type 2 diabetes mellitus.

Aim

The purpose of the present study is to investigate this issue among Japanese patients with type 2 diabetes mellitus.

Methods

A multicenter cross-sectional study was conducted in 847 Japanese patients with type 2 diabetes mellitus. Subjects were divided into quartiles according to age: (1) 19 ≤ age < 56, (2) 56 ≤ age < 64, (3) 64 ≤ age < 71, and (4) 71 ≤ age < 89. GERD was defined as present when a subject had a Carlsson–Dent self-administered questionnaire (QUEST) score ≥4.

Results

The prevalence of GERD was 31.5 %. Younger age was independently associated with a higher prevalence of GERD: the adjusted odds ratios (95 % confidence intervals) for GERD in relation to age < 56, 56 ≤ age < 64, 64 ≤ age < 71, and ≥71 were 3.73 (2.16–6.53), 1.98 (1.21–3.27), 1.66 (1.05–2.68), and 1.00 (reference), respectively (P for trend = 0.001). Among 201 patients with PPI or histamine H2-receptor antagonist (H2RA), less than 56 years of age was independently positively associated with GERD: the adjusted OR was 5.68 (95 % CI 1.55–22.18) (P for trend = 0.02).

Conclusions

Younger age may be independently positively associated with GERD among Japanese type 2 diabetes mellitus patients, regardless of the use of PPI or H2RA.

Keywords

Age Diabetes Esophagitis Nonerosive reflux disease Young 

Notes

Acknowledgments

This study was supported by JSPS KAKENHI Grants (21790583 and 23790697). We would like to thank Teruhisa Ueda from Ehime Prefectural Central Hospital, Masamoto Torisu from Saiseikai Saijo Hospital, Hisaka Minami from Ehime Niihama Hospital, Morikazu Onji from Saiseikai Imabari Hospital, Koutastsu Maruyama and Takeshi Tanigawa from Juntendo University, Eriko Kawamoto from University of The Ryukyus, Tomo Kogama and Keiko Kikuchi from Ehime University, and Eri Furukawa from Furukawa Clinic.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yoshio Ikeda
    • 1
  • Shinya Furukawa
    • 2
    • 3
    Email author
  • Takenori Sakai
    • 4
  • Tetsuji Niiya
    • 5
  • Hiroaki Miyaoka
    • 6
  • Teruki Miyake
    • 7
  • Shin Yamamoto
    • 8
  • Hidenori Senba
    • 2
    • 7
  • Yasunori Yamamoto
    • 1
  • Eiji Arimitsu
    • 7
  • Sen Yagi
    • 9
  • Hiroki Utsunomiya
    • 1
  • Keiko Tanaka
    • 2
    • 3
  • Eiji Takeshita
    • 9
  • Bunzo Matsuura
    • 8
  • Yoshihiro Miyake
    • 2
    • 3
  • Yoichi Hiasa
    • 7
  1. 1.Endoscopy CenterEhime University HospitalToonJapan
  2. 2.Department of Epidemiology and Preventive MedicineEhime University Graduate School of MedicineToonJapan
  3. 3.Epidemiology and Medical Statistics Unit, Translational Research CenterEhime University HospitalToonJapan
  4. 4.Department of Internal MedicineYawatahama General City HospitalYawatahamaJapan
  5. 5.Department of Internal MedicineMatsuyama Shimin HospitalMatsuyamaJapan
  6. 6.Department of Internal MedicineSaiseikai Matsuyama HospitalMatsuyamaJapan
  7. 7.Department of Gastroenterology and MetabologyEhime University Graduate School of MedicineToonJapan
  8. 8.Department of Lifestyle-related Medicine and EndocrinologyEhime University Graduate School of MedicineToonJapan
  9. 9.Department of Inflammatory Bowel Diseases and TherapeuticsEhime University Graduate School of MedicineToonJapan

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