Age and Prevalence of Esophageal Reflux Disease in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study
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Only limited epidemiological evidence exists regarding the relationship between age and gastroesophageal reflux disease (GERD) among Japanese patients with type 2 diabetes mellitus.
The purpose of the present study is to investigate this issue among Japanese patients with type 2 diabetes mellitus.
A multicenter cross-sectional study was conducted in 847 Japanese patients with type 2 diabetes mellitus. Subjects were divided into quartiles according to age: (1) 19 ≤ age < 56, (2) 56 ≤ age < 64, (3) 64 ≤ age < 71, and (4) 71 ≤ age < 89. GERD was defined as present when a subject had a Carlsson–Dent self-administered questionnaire (QUEST) score ≥4.
The prevalence of GERD was 31.5 %. Younger age was independently associated with a higher prevalence of GERD: the adjusted odds ratios (95 % confidence intervals) for GERD in relation to age < 56, 56 ≤ age < 64, 64 ≤ age < 71, and ≥71 were 3.73 (2.16–6.53), 1.98 (1.21–3.27), 1.66 (1.05–2.68), and 1.00 (reference), respectively (P for trend = 0.001). Among 201 patients with PPI or histamine H2-receptor antagonist (H2RA), less than 56 years of age was independently positively associated with GERD: the adjusted OR was 5.68 (95 % CI 1.55–22.18) (P for trend = 0.02).
Younger age may be independently positively associated with GERD among Japanese type 2 diabetes mellitus patients, regardless of the use of PPI or H2RA.
KeywordsAge Diabetes Esophagitis Nonerosive reflux disease Young
This study was supported by JSPS KAKENHI Grants (21790583 and 23790697). We would like to thank Teruhisa Ueda from Ehime Prefectural Central Hospital, Masamoto Torisu from Saiseikai Saijo Hospital, Hisaka Minami from Ehime Niihama Hospital, Morikazu Onji from Saiseikai Imabari Hospital, Koutastsu Maruyama and Takeshi Tanigawa from Juntendo University, Eriko Kawamoto from University of The Ryukyus, Tomo Kogama and Keiko Kikuchi from Ehime University, and Eri Furukawa from Furukawa Clinic.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- 6.Sun H, Yi L, Wu P, Li Y, Luo B, Xu S. Prevalence of gastroesophageal reflux disease in type 2 diabetes mellitus. Gastroenterol Res Pract 2014; Article ID 601571, 4.Google Scholar
- 28.Nonaka T, Kessoku T, Ogawa Y, et al. Comparative study of 2 different questionnaires in Japanese patients: the quality of life and utility evaluation survey technology questionnaire (QUEST) versus the frequency scale for the symptoms of gastroesophageal reflux disease questionnaire (FFSG). J Neurogastroenterol Motil. 2013;19:54–60.CrossRefPubMedPubMedCentralGoogle Scholar