Digestive Diseases and Sciences

, Volume 61, Issue 9, pp 2465–2476 | Cite as

Changes of HBV DNA After Chemoembolization for Hepatocellular Carcinoma and the Efficacy of Antiviral Treatment

  • Xiao-Jun Lin
  • Xiang-Ming LaoEmail author
  • Ming Shi
  • Sheng-Ping Li


Unlike systemic chemotherapy for hematological malignancies with hepatitis B virus (HBV) infection, transarterial chemoembolization (TACE) for HBV-related hepatocellular carcinoma (HCC) has only recently been reported to cause HBV reactivation and subsequent hepatitis. Most patients with HBV-related HCC have an underlying disease with liver fibrosis or cirrhosis, and TACE may potentially induce HBV reactivation and liver decompensation. Currently, there are no clinical guidelines for managing TACE-caused HBV reactivation. In this review, we summarize the changes of HBV status and liver function after TACE and the effect of antiviral treatment before, during, or after TACE.


Antiviral therapy Hepatitis B virus HBV reactivation Hepatocellular carcinoma Liver function Transarterial chemoembolization Nucleotide/nucleoside analogues 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Xiao-Jun Lin
    • 1
    • 2
    • 3
  • Xiang-Ming Lao
    • 1
    • 2
    • 3
    Email author
  • Ming Shi
    • 1
    • 2
    • 3
  • Sheng-Ping Li
    • 1
    • 2
    • 3
  1. 1.Department of Hepatobiliary OncologySun Yat-sen University Cancer CenterGuangzhouPeople’s Republic of China
  2. 2.State Key Laboratory of Southern ChinaGuangzhouPeople’s Republic of China
  3. 3.Collaborative Innovation Center for Cancer MedicineGuangzhouPeople’s Republic of China

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