Digestive Diseases and Sciences

, Volume 61, Issue 6, pp 1661–1668 | Cite as

Risk of Advanced Colorectal Neoplasia According to the Number of High-Risk Findings at Index Colonoscopy: A Korean Association for the Study of Intestinal Disease (KASID) Study

  • Yoon Suk Jung
  • Dong Il ParkEmail author
  • Won Hee KimEmail author
  • Chang Soo Eun
  • Soo-Kyung Park
  • Bong Min Ko
  • Geom Seog Seo
  • Jae Myung Cha
  • Jae Jun Park
  • Kyeong Ok Kim
  • Chang Mo Moon
  • Yunho Jung
  • Eun Soo Kim
  • Seong Ran Jeon
  • Chang Kyun Lee
Original Article



Data regarding outcomes for patients with multiple findings for high-risk adenomas are scarce.


To compare the risk for colorectal neoplasm (CRN) recurrence according to the number of high-risk findings.


This was a retrospective and multicenter study. Patients who had one or more high-risk adenomas at the index colonoscopy and underwent follow-up colonoscopy 2.5 or more years after the index colonoscopy were included. The number of high-risk findings was defined as follows: number of adenomas larger than 1 cm + number of adenomas with HGD + number of adenomas with a villous component + existence (counted as 1) or nonexistence (counted as 0) of three or more adenomas.


A total of 1646 patients were included, and the mean duration between index and follow-up colonoscopy was approximately 4 years. The cumulative incidence rate of recurrent advanced CRN in patients with three or more high-risk findings was higher than that in patients with one or two high-risk findings (p < 0.001). However, the difference in 3-year cumulative incidence rates of recurrent advanced CRN between the two groups was not great, although it was statistically significant (4.8 vs. 2.3 %, p = 0.039).


A 3-year surveillance interval for patients with multiple high-risk findings, regardless of the number of high-risk findings, appears reasonable.


Colonoscopy High-risk adenoma Colorectal neoplasia Recurrence 


Compliance with ethical standards

Conflicts of interest



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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yoon Suk Jung
    • 1
  • Dong Il Park
    • 1
    Email author
  • Won Hee Kim
    • 2
    Email author
  • Chang Soo Eun
    • 3
  • Soo-Kyung Park
    • 1
  • Bong Min Ko
    • 4
  • Geom Seog Seo
    • 5
  • Jae Myung Cha
    • 6
  • Jae Jun Park
    • 7
  • Kyeong Ok Kim
    • 8
  • Chang Mo Moon
    • 9
  • Yunho Jung
    • 10
  • Eun Soo Kim
    • 11
  • Seong Ran Jeon
    • 12
  • Chang Kyun Lee
    • 13
  1. 1.Department of Internal Medicine, Kangbuk Samsung Hospital, School of MedicineSungkyunkwan UniversitySeoulKorea
  2. 2.Digestive Disease Center, CHA Bundang Medical CenterCHA UniversitySeongnam-siKorea
  3. 3.Department of Internal MedicineHanyang University Guri HospitalGuriKorea
  4. 4.Department of Internal Medicine, Digestive Disease Center and Research InstituteSoonchunhyang University School of MedicineBucheonKorea
  5. 5.Department of Internal Medicine, Digestive Disease Research InstituteWonkwang University College of MedicineIksanKorea
  6. 6.Department of Internal Medicine, Kyung Hee University Hospital at Gang DongKyung Hee University School of MedicineSeoulKorea
  7. 7.Division of Gastroenterology, Department of Internal Medicine, Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea
  8. 8.Division of Gastroenterology and Hepatology, Department of Internal MedicineYeungnam University College of MedicineDaeguKorea
  9. 9.Department of Internal Medicine, School of MedicineEwha Womans UniversitySeoulKorea
  10. 10.Division of Gastroenterology, Department of MedicineSoonchunhyang University College of MedicineCheonanKorea
  11. 11.Division of Gastroenterology, Department of Internal Medicine, School of MedicineKeimyung UniversityDaeguKorea
  12. 12.Institute for Digestive Research, Digestive Disease Center, College of MedicineSoonchunhyang UniversitySeoulKorea
  13. 13.Department of Internal Medicine, School of MedicineKyung Hee UniversitySeoulKorea

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