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Digestive Diseases and Sciences

, Volume 61, Issue 5, pp 1314–1324 | Cite as

Role of MicroRNAs in NAFLD/NASH

  • Gyongyi SzaboEmail author
  • Timea Csak
Review

Abstract

MicroRNAs (miRNAs) are highly conserved, small, 18–25 nucleotide, non-coding RNAs that regulate gene expression at the post-transcriptional level. Each miRNA can regulate hundreds of target genes, and vice versa each target gene can be regulated by numerous miRNAs, suggesting a very complex network and explaining how miRNAs play pivotal roles in fine-tuning essentially all biological processes in all cell types in the liver. Here, we summarize the current knowledge on the role of miRNAs in the pathogenesis and diagnosis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with an outlook to the broader aspects of metabolic syndrome. Furthermore, we discuss the role of miRNAs as potential biomarkers and therapeutic targets in NAFLD/NASH.

Keywords

MicroRNAs NASH NAFLD 

Notes

Compliance with ethical standards

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Brookdale University Hospital and Medical CenterBrooklynUSA

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