Digestive Diseases and Sciences

, Volume 60, Issue 8, pp 2454–2462 | Cite as

The Trend of Inflammatory Bowel Diseases in Taiwan: A Population-Based Study

  • Chia-Jung Kuo
  • Kuang-Hui Yu
  • Lai-Chu See
  • Cheng-Tang ChiuEmail author
  • Ming-Yao Su
  • Chen-Ming Hsu
  • Chang-Fu Kuo
  • Meng-Jiun Chiou
  • Jia-Rou Liu
  • Hung-Wei Wang
Original Article


Background and Aim

The purpose of this study was to estimate the sex- and age-specific incidence rates of inflammatory bowel diseases (IBD) in Taiwan. Site-specific cancer occurred in patients with IBD would be reported, too.


A retrospective study by analyzing the data from the National Health Insurance Research Database of Taiwan.


Between 2000 and 2010, the overall incidence rate of Crohn’s disease (CD) and ulcerative colitis (UC) was 0.208 and 0.838 per 100,000 person-years. For male, the incidence rate of CD was 0.195 (95 % CI 0.113–0.276) per 100,000 persons in 2000 and increased to 0.318 (95 % CI 0.216–0.421) per 100,000 persons in 2010. For female, the incidence rate of CD was 0.092 (95 % CI 0.035–0.149) per 100,000 persons in 2000 and increased to 0.210 (95 % CI 0.128–0.293) per 100,000 persons in 2010. For male, the incidence rate of UC was 0.690 (95 % CI 0.537–0.843) per 100,000 persons in 2000 and increased to 1.351 (95 % CI, 1.140–1.562) per 100,000 persons in 2010. For female, the incidence rate of UC was 0.386 (95 % CI 0.269–0.503) per 100,000 persons in 2000 and increased to 0.858 (95 % CI 0.691–1.024) per 100,000 persons in 2010. Among the CD patients, 0.19 % had colorectal cancers (1/519). Among the UC patients, 0.24 % had colorectal cancers (5/2098).


This nationwide population-based longitudinal epidemiological study of IBD in Taiwan provides data for future global comparisons.


Crohn’s disease Ulcerative colitis Sex- and age-specific incidence Cancer 



CJ Kuo, KH Yu, CT Chiu, MY Su, CM Hsu, CF Kuo, and HW Wang developed the study concept and design and provided the critical revision of the manuscript for important intellectual content. LC See, MJ Chiou, and JR Liu collected and interpreted the data. All authors approved the final version of the manuscript.

Conflict of interest

The authors report no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Chia-Jung Kuo
    • 1
    • 2
  • Kuang-Hui Yu
    • 2
    • 3
  • Lai-Chu See
    • 2
    • 4
    • 5
  • Cheng-Tang Chiu
    • 1
    • 2
    Email author
  • Ming-Yao Su
    • 1
    • 2
  • Chen-Ming Hsu
    • 1
    • 2
  • Chang-Fu Kuo
    • 2
    • 3
  • Meng-Jiun Chiou
    • 2
    • 4
    • 5
  • Jia-Rou Liu
    • 2
    • 4
    • 5
  • Hung-Wei Wang
    • 1
  1. 1.Department of Gastroenterology and Hepatology, College of Medicine, Chang Gung Memorial HospitalChang Gung UniversityTaoyuanTaiwan, ROC
  2. 2.College of MedicineChang Gung UniversityTaoyuanTaiwan, ROC
  3. 3.Division of Rheumatology, Allergy, and ImmunologyChang Gung Memorial HospitalTaoyuanTaiwan, ROC
  4. 4.Department of Public Health, Biostatistics Consulting CenterChang Gung UniversityTaoyuanTaiwan, ROC
  5. 5.Biostatistics Core Laboratory, Molecular Medical Research CenterChang Gung UniversityTaoyuanTaiwan, ROC

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