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Digestive Diseases and Sciences

, Volume 60, Issue 7, pp 2070–2076 | Cite as

High Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the USA

  • Christie E. Choi
  • Amnon Sonnenberg
  • Kevin Turner
  • Robert M. GentaEmail author
Original Article

Abstract

Background

The prevalence of H. pylori infection and the incidence of gastric cancer differ widely around the world, but it is unclear whether these differences are mirrored in the multiethnic population of the USA.

Aims

This study tested the hypothesis that the prevalence of both H. pylori infection and gastric preneoplastic lesions in US residents of Hispanic and Asian ancestry reflects the incidence of gastric cancer in their ancestral countries.

Methods

A total of 799,075 subjects with gastric biopsies extracted from a national pathology database were stratified into the following ancestries: Indian, Hispanic, Vietnamese, Chinese, Japanese Korean, and other Americans (Caucasian and African-American US residents). The prevalence of H. pylori, intestinal metaplasia, and atrophic gastritis was compared among different ethnic groups using age- and sex-adjusted odds ratios and linear regression.

Results

Patients of Indian, Hispanic, Vietnamese, Chinese, Japanese, and Korean ancestry had significantly higher prevalence rates of H. pylori gastritis, intestinal metaplasia, and atrophy than other Americans. The prevalence of intestinal metaplasia and atrophy among different ethnic groups did not correlate with H. pylori prevalence, but did correlate highly significantly with gastric cancer incidence in the patients’ ancestral countries.

Conclusions

Various US ethnic groups have significantly different prevalence rates of H. pylori gastritis and gastric preneoplastic lesions. Patients’ ethnicity needs be considered in the prevention and early detection of gastric cancer.

Keywords

Gastric cancer Gastric intestinal metaplasia Atrophic gastritis H. pylori Helicobacter Ethnicity 

Notes

Conflict of interest

Kevin Turner and Robert Genta are employees of Miraca Life Sciences. Christie Choi and Amnon Sonnenberg declare no relevant conflicts.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Christie E. Choi
    • 1
    • 2
  • Amnon Sonnenberg
    • 5
  • Kevin Turner
    • 1
    • 3
  • Robert M. Genta
    • 1
    • 4
    Email author
  1. 1.Miraca Life Sciences Research InstituteIrvingUSA
  2. 2.Department of MedicineUniversity of Texas Southwestern Medical SchoolDallasUSA
  3. 3.Department of PathologyUniversity of Texas Southwestern Medical SchoolDallasUSA
  4. 4.Departments of Pathology and MedicineUniversity of Texas Southwestern Medical SchoolDallasUSA
  5. 5.Department of Medicine (Gastroenterology), Portland VAMCOHSUPortlandUSA

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