Digestive Diseases and Sciences

, Volume 59, Issue 10, pp 2536–2543 | Cite as

Endoscopic Resection for Undifferentiated Early Gastric Cancer: Focusing on Histologic Discrepancies Between Forceps Biopsy-Based and Endoscopic Resection Specimen-Based Diagnosis

  • Byung-Hoon Min
  • Ki Joo Kang
  • Jun Haeng LeeEmail author
  • Eun Ran Kim
  • Yang Won Min
  • Poong-Lyul Rhee
  • Jae J. Kim
  • Jong Chul Rhee
  • Kyoung-Mee Kim
Original Article



Before endoscopic resection (ER), a considerable number of undifferentiated early gastric cancer (UD-EGC) cases were initially diagnosed as atypical glands, dysplasia, or differentiated EGC (D-EGC) based on forceps biopsy specimens. As UD-EGC carries a high risk of resection margin involvement, identifying the predictive factors for UD-EGC cases with histologic discrepancy (HD) is of clinical importance.


To investigate the outcomes of ER for UD-EGC and to identify the predictive factors for UD-EGC with HD.


Among 2,194 EGC lesions treated by ER, 59 lesions were finally diagnosed as UD-EGC and 50 UD-EGC cases showed HD. The demographic and endoscopic characteristics were compared between D-EGC and UD-EGC with HD, and the predictive factors for the latter were investigated among cases of forceps biopsy-based diagnosis of atypical glands, dysplasia, or D-EGC.


UD-EGC showed significantly higher rate of lateral margin involvement compared to D-EGC (18.6 vs. 3.4 %). Among the UD-EGC cases meeting the expanded criteria and not involving additional surgery, no local or extragastric tumor recurrence was observed during the median follow-up of 27.5 months. Multivariate analysis demonstrated that age (≤60 years), female gender, gastric body, flat or depressed type, and tumor size (>2 cm) were independent predictive factors for UD-EGC with HD among cases of forceps biopsy-based diagnosis of atypical glands, dysplasia, or D-EGC.


For lesions with predictive factors for UD-EGC with HD, a circumferential mapping biopsy before ER or wide marking during ER could be considered to avoid the potential risk of incomplete resection.


Undifferentiated cancer Histologic discrepancy Endoscopic resection Clinical outcome 


Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Byung-Hoon Min
    • 1
  • Ki Joo Kang
    • 2
  • Jun Haeng Lee
    • 1
    Email author
  • Eun Ran Kim
    • 1
  • Yang Won Min
    • 1
  • Poong-Lyul Rhee
    • 1
  • Jae J. Kim
    • 1
  • Jong Chul Rhee
    • 1
  • Kyoung-Mee Kim
    • 3
  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Department of Medicine, Hallym University College of Medical SchoolHallym University Sacred Heart HospitalAnyangKorea
  3. 3.Department of Pathology, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea

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