Digestive Diseases and Sciences

, Volume 59, Issue 9, pp 2228–2235

Clinical Presentation and Disease Course of Inflammatory Bowel Disease Differs by Race in a Large Tertiary Care Hospital

  • M. Anthony Sofia
  • David T. Rubin
  • Ningqi Hou
  • Joel Pekow
Original Article

DOI: 10.1007/s10620-014-3160-0

Cite this article as:
Sofia, M.A., Rubin, D.T., Hou, N. et al. Dig Dis Sci (2014) 59: 2228. doi:10.1007/s10620-014-3160-0

Abstract

Background

While the incidence of inflammatory bowel disease (IBD) among African-Americans (AAs) is increasing, there is limited understanding of phenotypic differences and outcomes by race.

Aim

To describe disease characteristics of AA patients compared to Caucasian (Ca) patients in a tertiary care population.

Methods

We performed a cross-sectional review of the IBD registry at the University of Chicago from January 2008 to January 2013. Data regarding race, phenotype, disease onset, disease duration, medical therapy, and surgical treatment were abstracted from the database, then compared via Pearson’s chi-square analysis, Kruskal–Wallis analysis, and logistic regression with a significance level of p < 0.05.

Results

A total of 1,235 patients with Crohn’s disease (CD) and 541 patients with ulcerative colitis (UC) included 108 AA CD patients and 28 AA UC patients. AA CD patients had an increased rate of IBD-related arthralgias (36.5 vs. 23.9 %, p < 0.01) and surgery (p < 0.01), less ileal involvement (57.8 vs. 71.0 %, p < 0.01), and no differences for other extraintestinal manifestations or disease locations compared to Ca CD patients. AA UC patients were older at diagnosis, had an increased rate of arthralgias (28.6 vs. 14.6 %, p = 0.047) and ankylosing spondylitis/sacroiliitis (7.1 vs. 1.6 %, p = 0.035), with no differences for disease extent or rate of IBD-related surgeries compared to Ca UC patients. There were no differences in medication usage by race for CD and UC patients.

Conclusion

We identified significant differences in disease characteristics and extraintestinal manifestations between AA and Ca IBD patients in a large tertiary care population. These results have implications for future genotype-phenotype studies.

Keywords

Ulcerative colitis Crohn’s disease Epidemiology Race African-American 

Abbreviations

IBD

Inflammatory bowel disease

Ca

Caucasian

AA

African-American

CD

Crohn’s disease

UC

Ulcerative colitis

5-ASA

5-Aminosalicylate

IPAA

Ileal pouch-anal anastomosis

Supplementary material

10620_2014_3160_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 16 kb)
10620_2014_3160_MOESM2_ESM.docx (15 kb)
Supplementary material 2 (DOCX 14 kb)

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • M. Anthony Sofia
    • 1
    • 5
  • David T. Rubin
    • 1
    • 2
    • 6
  • Ningqi Hou
    • 3
    • 7
  • Joel Pekow
    • 1
    • 2
    • 4
  1. 1.Department of MedicineUniversity of ChicagoChicagoUSA
  2. 2.Inflammatory Bowel Disease CenterUniversity of ChicagoChicagoUSA
  3. 3.Department of Health StudiesUniversity of ChicagoChicagoUSA
  4. 4.ChicagoUSA
  5. 5.ChicagoUSA
  6. 6.ChicagoUSA
  7. 7.ChicagoUSA

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