Digestive Diseases and Sciences

, Volume 59, Issue 8, pp 1917–1924 | Cite as

Can Endoscopic Ultrasound-Guided Fine Needle Aspiration Offer Clinical Benefit for Thick-Walled Gallbladders?

  • Takeshi OguraEmail author
  • Yoshitaka Kurisu
  • Daisuke Masuda
  • Akira Imoto
  • Saori Onda
  • Rieko Kamiyama
  • Michihiro Hayashi
  • Malak Mohamed
  • Kazuhisa Uchiyama
  • Kazuhide Higuchi
Original Article



No previous studies have compared cytology obtained under endoscopic transpapillary gallbladder drainage (ETGD) and EUS-guided fine needle aspiration (EUS-FNA) for thick-walled gallbladders.


The present study investigated the diagnostic yield of bile cytology under ETGD and EUS-FNA for gallbladder tumors.


A total of 69 patients were diagnosed as having gallbladder wall thickening. Among these patients, 28 patients were diagnosed by clinical follow-up, solely by imaging such as computed tomography or by histological examination of surgical specimens. The remaining 41 patients underwent ETGD and/or EUS-FNA. In these 41 patients, the clinical data collected included gender, age, diameter of gallbladder wall, site of gallbladder wall thickening, final diagnosis, adverse events, and diagnostic yield of ETGD and EUS-FNA.


Cyto-histological diagnosis with EUS-FNA was higher than that with ETGD, with a sensitivity of 100 versus 71 %, specificity of 100 versus 94 %, and accuracy of 100 versus 88 %, respectively, in the two groups. In addition, the sampling adequacy of EUS-FNA was 100 %. Adverse events were seen in five patients in the ETGD group (mild pancreatitis), although no adverse events were seen in the EUS-FNA group (P = 0.08).


Our results suggest that EUS-FNA can be safely performed for the diagnosis of gallbladder lesions. Further, this procedure may be the diagnostic method of choice over cytology of bile juice obtained via ETGD to obtain histological evidence of gallbladder cancer.


Endoscopic ultrasound Gallbladder carcinoma Thick-walled gallbladder Endoscopic retrograde pancreatocholangiogray 


Conflict of interest


Supplementary material

10620_2014_3100_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 12 kb)

Supplementary material 2 (AVI 6,782 kb)

Supplementary material 3 (AVI 6,025 kb)


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Takeshi Ogura
    • 1
    Email author
  • Yoshitaka Kurisu
    • 2
  • Daisuke Masuda
    • 1
  • Akira Imoto
    • 1
  • Saori Onda
    • 1
  • Rieko Kamiyama
    • 1
  • Michihiro Hayashi
    • 3
  • Malak Mohamed
    • 4
  • Kazuhisa Uchiyama
    • 3
  • Kazuhide Higuchi
    • 1
  1. 1.Second Department of Internal MedicineOsaka Medical CollegeOsakaJapan
  2. 2.Department of PathologyOsaka Medical CollegeOsakaJapan
  3. 3.Department of General and Gastroenterological SurgeryOsaka Medical CollegeOsakaJapan
  4. 4.Department of GastroenterologySohag UniversitySohâgEgypt

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