Digestive Diseases and Sciences

, Volume 59, Issue 8, pp 1688–1697

Molecular Therapies in Hepatocellular Carcinoma: What Can We Target?

  • Roberto Galuppo
  • Dinesh Ramaiah
  • Oscar Moreno Ponte
  • Roberto Gedaly
Review

Abstract

Numerous signaling pathways, such as Ras/Raf/MAPK, have been implicated in hepatic carcinogenesis. There are at least 35 combination therapy studies for advanced stage hepatocellular carcinoma (HCC) ongoing, and numerous reagents are being tested targeting novel signaling cascades. The management of HCC has changed substantially in recent times, and the successful development of sorafenib has prompted further expansion on molecular targeted therapies to potentially inhibit different pathways in hepatocarcinogenesis.

Keywords

Hepatocellular carcinoma Sorafenib Ras/Raf/MAPK Liver cancer stem cells Epidermal growth factor 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Roberto Galuppo
    • 1
  • Dinesh Ramaiah
    • 1
  • Oscar Moreno Ponte
    • 1
  • Roberto Gedaly
    • 1
  1. 1.Division of Transplantation Surgery, Department of Surgery, College of MedicineUniversity of KentuckyLexingtonUSA

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