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Digestive Diseases and Sciences

, Volume 59, Issue 7, pp 1502–1508 | Cite as

Children with Celiac Disease Are More Likely to Have Attended Hospital for Prior Respiratory Syncytial Virus Infection

  • Anna Röckert TjernbergEmail author
  • Jonas F. Ludvigsson
Original Article

Abstract

Background and Aim

The purpose of this study was to examine the association between celiac disease (CD) and prior respiratory syncytial virus (RSV) infection or any viral bronchiolitis.

Methods

This was a retrospective case–control study. During 2006–2008 small intestinal biopsy data were collected from Sweden’s 28 pathology departments. We identified 3,835 children diagnosed with CD (villous atrophy, Marsh stage 3) before the age of 2 years in 1987 or later. Using conditional logistic regression we calculated odds ratios (ORs) for having a prior diagnosis of respiratory syncytial virus or other viral bronchiolitis compared to 19,102 age- and sex-matched controls.

Results

Of the 3,835 children with CD, 36 (0.9 %) had a prior diagnosis of RSV compared to 117/19,102 (0.6 %) matched controls. This corresponded to an OR of 1.46 (95 % CI 1.03–2.07). ORs were similar in girls and boys. The highest ORs were seen in children developing early CD (before 1 year of age (OR 1.82; 95 % CI 0.91–3.62). Prior record of any type of viral bronchiolitis was found in 3.4 % (132/3,835) of individuals with CD and in 2.0 % (390/19,102) of the matched controls corresponding to an OR of 1.60 (95 % CI 1.33–1.92).

Conclusions

Children with CD diagnosed <2 years of age were more likely to have attended hospital for a prior RSV infection or any viral bronchiolitis than other children.

Keywords

Autoimmunity Bronchiolitis Child Coeliac Infant Inflammation Respiratory syncytial virus 

Abbreviations

CD

Celiac disease

CI

Confidence interval

OR

Odds ratio

RSV

Respiratory syncytial virus

VA

Villous atrophy

Notes

Acknowledgments

ART was funded by Kalmar County Council. JFL was supported by grants from The Swedish Society of Medicine, the Swedish Research Council—Medicine (522-2A09-195), the Swedish Celiac Society, and the Fulbright Commission.

Conflict of interest

None.

Ethical standard

This project (2006/633-31/4) was approved by the Research Ethics Committee of the Karolinska Institute, Sweden on June 14, 2006.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Anna Röckert Tjernberg
    • 1
    Email author
  • Jonas F. Ludvigsson
    • 2
    • 3
  1. 1.Department of PediatricsKalmar County HospitalKalmarSweden
  2. 2.Department of PediatricsÖrebro University HospitalÖrebroSweden
  3. 3.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden

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