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Digestive Diseases and Sciences

, Volume 59, Issue 5, pp 1036–1041 | Cite as

Portal Hypertensive Enteropathy Diagnosed by Capsule Endoscopy in Cirrhotic Patients: A Nationwide Multicenter Study

  • Seong Ran Jeon
  • Jin-Oh KimEmail author
  • Ji-Beom Kim
  • Byong Duk Ye
  • Dong Kyung Chang
  • Ki-Nam Shim
  • Dae Young Cheung
  • Jin Soo Kim
  • Myung Gyu Choi
  • Hyun Joo Song
  • Yun Jeong Lim
  • Soo Jung Park
  • Ji Hyun Kim
  • Jeong Seop Moon
  • Yoon Tae Jeen
  • The Korean Gut Image Study Group
Original Article

Abstract

Background and Aim

Due to the limited data on portal hypertensive enteropathy (PHE), the prevalence of and clinical factors related to PHE remain unclear. This study determined the prevalence of PHE using capsule endoscopy (CE) and PHE-related clinical factors.

Methods

This was a retrospective multicenter study using the Capsule Endoscopy Nationwide Database Registry. From 2,879 cases that underwent CE, 45 cirrhosis patients with portal hypertension (PH) were enrolled and divided into PHE (n = 18) and non-PHE (n = 27) groups. From computed tomography (CT) images, six secondary changes due to PH were scored to give a total CT score of 0–6. The main outcome variable was the prevalence of PHE and PHE-related clinical factors.

Results

The prevalence of PHE was 40 %. Comparing the PHE and non-PHE groups, the most common findings were angiodysplasias in 55.7 % (vs. 7.4 %, p = 0.001) and varices in 38.9 % (vs. 0 %, p = 0.001). Active bleeding was observed in 16.6 and 3.7 %, respectively, but this difference was not significant. In the univariate analysis, Child–Turcotte–Pugh class C (p = 0.002) and a high CT score (≥3 vs. <3, p = 0.004) were significantly associated with PHE. However, only a high CT score was significant in the multivariate analysis (odds ratio 11.19; 95 % confidence interval, 1.59-infinity; p = 0.040).

Conclusions

The prevalence of PHE was 40 %, and it might be more prevalent in cirrhosis patients with PH who have a high CT score. CE is a useful diagnostic tool for evaluating PHE in cirrhosis patients with PH.

Keywords

Capsule endoscopy Enteropathy Portal hypertension Liver cirrhosis 

Notes

Acknowledgments

We gratefully and sincerely thank Ji Sung Lee, PhD, Biostatistical Consulting Unit, Soonchunhyang University Medical Center, Seoul, Korea, who helped with the statistical analysis.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Seong Ran Jeon
    • 1
  • Jin-Oh Kim
    • 1
    Email author
  • Ji-Beom Kim
    • 2
  • Byong Duk Ye
    • 2
  • Dong Kyung Chang
    • 3
  • Ki-Nam Shim
    • 4
  • Dae Young Cheung
    • 5
  • Jin Soo Kim
    • 5
  • Myung Gyu Choi
    • 5
  • Hyun Joo Song
    • 6
  • Yun Jeong Lim
    • 7
  • Soo Jung Park
    • 8
  • Ji Hyun Kim
    • 9
  • Jeong Seop Moon
    • 10
  • Yoon Tae Jeen
    • 11
  • The Korean Gut Image Study Group
  1. 1.Department of Internal MedicineSoonchunhyang University College of MedicineSeoulKorea
  2. 2.Department of Internal MedicineUniversity of Ulsan College of MedicineSeoulKorea
  3. 3.Department of Internal MedicineSungkyunkwan University School of MedicineSeoulKorea
  4. 4.Department of Internal MedicineEwha Womans University School of MedicineSeoulKorea
  5. 5.Department of Internal MedicineThe Catholic University College of MedicineSeoulKorea
  6. 6.Department of Internal MedicineJeju National University School of MedicineChejuKorea
  7. 7.Department of Internal MedicineDongguk University College of MedicineGoyangKorea
  8. 8.Department of Internal MedicineYonsei University College of MedicineSeoulKorea
  9. 9.Department of Internal MedicineInje University College of MedicineBusanKorea
  10. 10.Department of Internal MedicineInje University College of MedicineSeoulKorea
  11. 11.Department of Internal MedicineKorea University College of MedicineSeoulKorea

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