Digestive Diseases and Sciences

, Volume 59, Issue 5, pp 1055–1062 | Cite as

Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis

  • Mei Lan Cui
  • Kook Hyun Kim
  • Ho Gak Kim
  • Jimin Han
  • Hyunsoo Kim
  • Kwang Bum Cho
  • Min Kyu Jung
  • Chang Min Cho
  • Tae Nyeun Kim
Original Paper



Acute pancreatitis is an acute inflammatory process of the pancreas with variable involvement of other regional tissues or remote organ systems. Acute fluid collections and pseudocyst formation are the most frequent complications of acute pancreatitis.


The aims of this study were to evaluate the incidence, risk factors, and clinical course of pancreatic fluid collections and pseudocyst formation following acute pancreatitis.


A prospective multicenter study was conducted in five participating centers with 302 patients diagnosed with acute pancreatitis from January 2011 to July 2012.


The incidence of pancreatic fluid collections and pseudocyst was 42.7 and 6.3 %, respectively. Patients with fluid collections were significantly younger, compared to those without fluid collections (51.5 ± 15.9 vs. 60.4 ± 16.5 years, P = 0.000). The proportion of alcoholic etiology (54.3 %) in patients with fluid collections was significantly higher compared to other etiologies (P = 0.000). C-reactive protein (CRP) (48 h) was significantly higher in patients with fluid collections, compared to patients without fluid collections (39.2 ± 77.4 vs. 15.1 ± 36.2 mg/dL, P = 0.016). LDH (48 h) was significantly higher in patients with pseudocyst formation, compared to patients with complete resolution (1,317.6 ± 706.4 vs. 478.7 ± 190.5 IU/L, P = 0.000). Pancreatic fluid collections showed spontaneous resolution in 69.8 % (90/129) and 84.2 % of the pseudocysts disappeared or decreased in size during follow up.


Age, CRP (48 h), and alcohol etiology are risk factors for pancreatic fluid collections. LDH (48 h) appears to be a risk factor for pseudocyst formation. Most pseudocysts showed a decrease in size or spontaneous resolution with conservative management.


Acute pancreatitis Fluid collections Pseudocyst Incidence 



This work was supported by the 2011 Yeungnam University Research Grant, and the grant of Research Institute of Medical Science, Catholic University of Daegu (2011).

Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mei Lan Cui
    • 1
  • Kook Hyun Kim
    • 1
  • Ho Gak Kim
    • 2
  • Jimin Han
    • 2
  • Hyunsoo Kim
    • 3
  • Kwang Bum Cho
    • 4
  • Min Kyu Jung
    • 5
  • Chang Min Cho
    • 5
  • Tae Nyeun Kim
    • 1
  1. 1.Division of Gastroenterology and Hepatology, Department of Internal MedicineYeungnam University College of MedicineTaeguKorea
  2. 2.Department of Internal MedicineCatholic University of Daegu School of MedicineTaeguKorea
  3. 3.Department of Internal MedicineDaegu Fatima HospitalTaeguKorea
  4. 4.Department of Internal MedicineKeimyung University School of MedicineTaeguKorea
  5. 5.Department of Internal MedicineKyungpook National University School of MedicineTaeguKorea

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