Thrombocytosis and Hepatocellular Carcinoma
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Thrombocytopenia has been reported to be both a risk factor for hepatocellular carcinoma (HCC) development as well as a prognostic factor. Many HCCs also occur in presence of normal platelets.
To examine a cohort of HCC patients with associated thrombocytosis.
Records were examined of a cohort of 634 biopsy-proven and randomly presenting HCC patients without thrombocytopenia.
In the total cohort, 52 patients were identified with thrombocytosis (platelet levels >400 × 109/L) and compared with 582 patients with normal platelet values. The average tumor sizes were 13.1 versus 8.8 cm (p < 0.0001), and their total average bilirubin levels were 0.9 versus 1.5 (p = 0.02), comparing thrombocytosis patients versus normal platelet count HCC patients. These differences were even more pronounced in patients with HCC sizes >5 cm. Thrombocytosis patients were younger and had less cirrhosis, but similar percent with hepatitis B or C or alcohol consumption.
Thrombocytosis in association with HCC occurs in patients with larger tumor sizes and better liver function.
KeywordsHCC Size Thrombocytosis Portal vein thrombosis
Portal vein thrombosis
White blood count
Computerized axial tomography
- Platelet units
- Bilirubin values
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