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Digestive Diseases and Sciences

, Volume 58, Issue 2, pp 344–348 | Cite as

Overlap Syndromes of Autoimmune Hepatitis: An Open Question

  • Marilena DurazzoEmail author
  • Alberto Premoli
  • Elena Paschetta
  • Paola Belci
  • Maurizio Spandre
  • Simona Bo
Review

Abstract

The headword “overlap syndromes” of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. These syndromes often represent a diagnostic and therapeutic challenge for hepatologists; it remains unclear whether these overlap syndromes form distinct entities or they are only variants of the major autoimmune liver diseases. The most frequent reported association occurs between autoimmune hepatitis and primary biliary cirrhosis, whereas the overlap between autoimmune hepatitis and primary sclerosing cholangitis is less frequent, typically at young age and often attendant with an inflammatory bowel disease. The choice therapy is based on ursodeoxycholic acid and immunosuppressive drugs, used at the same time or consecutively, according to the course of disease. The diagnostic scores for autoimmune hepatitis can help for diagnosis, even though their definitive soundness is lacking.

Keywords

Overlap syndrome Autoimmune hepatitis Primary biliary cirrhosis Primary sclerosing cholangitis 

Notes

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Marilena Durazzo
    • 1
    Email author
  • Alberto Premoli
    • 2
  • Elena Paschetta
    • 1
  • Paola Belci
    • 1
  • Maurizio Spandre
    • 1
  • Simona Bo
    • 1
  1. 1.Department of Internal MedicineUniversity of TurinTurinItaly
  2. 2.Department of Internal MedicineS. Lazzaro HospitalAlbaItaly

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