Digestive Diseases and Sciences

, Volume 58, Issue 2, pp 496–503 | Cite as

Clinical Course of Intestinal Behcet’s Disease During the First Five Years

  • Yoon Suk Jung
  • Jae Hee Cheon
  • Soo Jung Park
  • Sung Pil Hong
  • Tae Il Kim
  • Won Ho KimEmail author
Original Article



Little is known about the clinical course of patients with intestinal Behcet’s disease (BD). We aimed to evaluate the clinical course of intestinal BD during the first 5 years after diagnosis, and to identify factors that could predict the 5-year clinical course.


We reviewed the medical records of 130 intestinal BD patients who were regularly followed-up for at least 5 years at a single tertiary academic medical center between March 1986 and September 2011.


Of the five different clinical course patterns that we observed, persistent remission or mild clinical activity was the most frequent course (56.2 %). The majority of patients (74.6 %) had remission or mild clinical activity at 5 years, and only the minority (16.2 %) had multiple relapses or chronic symptoms. The clinical course of the first year after diagnosis of intestinal BD influenced the clinical course of the following years. Patients in the severe clinical course group were younger, and had a higher ESR, CRP level, and disease activity index for intestinal Behcet’s disease (DAIBD), and lower albumin level at diagnosis than patients in the mild clinical course group. Initial presentation with a high DAIBD was independently associated with a severe clinical course.


The clinical course of intestinal BD during the first 5 years was variable. A substantial proportion of patients went into remission or had a mild clinical activity, while some patients had a severe, debilitating clinical course as time progressed. High disease activity at diagnosis was a negative prognostic predictor.


Intestinal Behcet’s disease Clinical course Prognostic factors High disease activity 


Conflict of interest



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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yoon Suk Jung
    • 1
    • 2
  • Jae Hee Cheon
    • 1
  • Soo Jung Park
    • 1
  • Sung Pil Hong
    • 1
  • Tae Il Kim
    • 1
  • Won Ho Kim
    • 1
    Email author
  1. 1.Division of Gastroenterology, Department of Internal MedicineYonsei University College of MedicineSeodaemun-gu, SeoulKorea
  2. 2.Department of Internal MedicineKangbuk Samsung Hospital, Sungkyunkwan University School of MedicineSeoulKorea

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