Effect of Boswellia serrata on Antioxidant Status in an Experimental Model of Colitis Rats Induced by Acetic Acid
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Aim of the Study
To evaluate the antioxidant effect of an extract of the plant Boswellia serrata in an experimental model of acute ulcerative colitis induced by administration of acetic acid (AA) in rats.
Materials and Methods
The extract of B. serrata (34.2 mg/kg/day) was administered orally by gavage for 2 days before and after induction of colitis with AA diluted to 4 % and in a volume of 4 ml.
The anal sphincter pressure in the groups treated with B. serrata showed a significant increase compared to the colitis group (P < 0.001). Histological analysis of treated animals showed less edema with preservation of mucosal crypts. Lipid peroxidation showed a significant decrease in the treated groups compared to the colitis group (P < 0.001). The superoxide dismutase (SOD) enzyme activity showed a significant reduction in the treated groups compared to the colitis group (P < 0.001), the glutathione peroxidase (GPx) significantly increased in the treated groups compared to colitis group (P < 0.05), and the same was the result for enzyme activity glutathione (GSH; P < 0.05).
The extract of B. serrata has active antioxidant substances that exert protective effects in acute experimental colitis.
KeywordsAntioxidant Boswellia serrata Inflammation Oxidative stress Radical scavenger Ulcerative colitis
One-way analysis of variance
Inflammatory bowel disease
Inducible nitric oxide
Reactive oxygen species
Supported by grants from the Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundo de Incentivo à Pesquisa e Eventos (FIPE/ proj nº 110215) of the Hospital de Clínicas de Porto Alegre (HCPA), and Laboratório de Hepatologia e Gastroenterologia Experimental (HCPA/UFRGS) of the Universidade Federal do Rio Grande do Sul (UFRGS).
Conflict of interest
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