Digestive Diseases and Sciences

, Volume 57, Issue 8, pp 2144–2148

Hypovitaminosis D in Adults with Inflammatory Bowel Disease: Potential Role of Ethnicity

  • Yi-Tzu Nancy Fu
  • Nazira Chatur
  • Cindy Cheong-Lee
  • Baljinder Salh
Original Article

DOI: 10.1007/s10620-012-2130-7

Cite this article as:
Fu, YT.N., Chatur, N., Cheong-Lee, C. et al. Dig Dis Sci (2012) 57: 2144. doi:10.1007/s10620-012-2130-7

Abstract

Background

Although vitamin D deficiency occurs in inflammatory bowel disease (IBD), it is currently unclear to what extent ethnicity affects vitamin D levels. Our aim was therefore to determine the ethnic variation in serum 25-hydroxyvitamin D status and its association with disease severity in adults with IBD.

Methods

We conducted a prospective cohort study in ambulatory care IBD patients. Clinical disease severity was assessed through validated questionnaires. Serum 25-hydroxyvitamin D levels were used for vitamin D status. C-reactive protein (CRP), ferritin and hemoglobin (Hgb) levels were correlated with serum 25-hydroxyvitamin D levels.

Results

Sixty ulcerative colitis (UC) and forty Crohn’s disease (CD) patients were enrolled comprising 65 % Caucasians and 29 % South Asians. However, South Asians had consistently lower average serum 25-hydroxyvitamin D levels (All 44.8 ± 18.1 nmol/L, UC 48.2 ± 18.3 nmol/L, CD 24.3 ± 13.3 nmol/L). Hypovitaminosis D was found in 39 % of All, 36.7 % of UC and 42.5 % of CD patients. A significantly higher proportion of South Asians were vitamin D deficient when compared to Caucasians in All and CD groups (58.6 % vs. 30.8 %, p = 0.01 and 85.7 % vs. 32.3 %, p < 0.01, respectively).

Conclusions

A significantly higher percentage of South Asians had hypovitaminosis D when compared to Caucasians. Disease severity trended towards an inverse relationship with vitamin D status in all South Asian and Caucasian CD patients, although most patients in this study had only mild to moderate disease. We suggest that vitamin D supplementation should be considered in all adult IBD patients.

Keywords

Inflammatory bowel disease Vitamin D Hypovitaminosis D Ethnic variation Disease severity Disease activity 

Supplementary material

10620_2012_2130_MOESM1_ESM.doc (256 kb)
Supplementary material 1 (DOC 255 kb)

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yi-Tzu Nancy Fu
    • 1
  • Nazira Chatur
    • 1
  • Cindy Cheong-Lee
    • 1
  • Baljinder Salh
    • 1
  1. 1.Division of Gastroenterology, Department of Medicine, Gordon and Leslie Diamond Health Care CentreUniversity of British ColumbiaVancouverCanada

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