Digestive Diseases and Sciences

, Volume 57, Issue 4, pp 967–972 | Cite as

Impact of Helicobacter pylori Infection and Microscopic Duodenal Histopathological Changes on Clinical Symptoms of Patients with Functional Dyspepsia

  • Seyed Amir Mirbagheri
  • Nasim KhajaviradEmail author
  • Nasser Rakhshani
  • Mohammad Reza Ostovaneh
  • Seyed Mahmood Eshagh Hoseini
  • Vahid Hoseini
Original Article



To evaluate the microscopic histopathological changes in duodenal tissue and its relationship to the severity of symptoms in patients with functional dyspepsia while taking the effect of Helicobacter pylori (H. pylori) infection into account.


Several gastric and duodenal biopsy specimens were obtained in 217 patients with functional dyspepsia and were evaluated for H. pylori infection and histopathological changes. Severity of symptoms was assessed by Leeds Dyspepsia Questionnaire (LDQ) and its relationship to histopathological changes and H. pylori infection status was assessed.


Helicobacter pylori infection was associated with presence and severity of microscopic duodenitis (p < 0.001). In H. pylori-infected patients, the presence of microscopic duodenitis was independent of microscopic gastritis (p = 0.74). Severity of dyspepsia symptoms was not higher in H. pylori-infected patients than non-infected patients (p = 0.15), but in the presence of H. pylori infection and microscopic gastritis, microscopic duodenitis significantly worsened the LDQ symptom severity score (p < 0.001). In multivariate analysis, the odds of experiencing severe symptoms in patients with severe microscopic duodenitis was 2.22 times greater than in individuals with very mild, mild, or moderate duodenitis.


Microscopic duodenitis in H. pylori-infected patients may play a major role in producing and aggravating symptoms in FD patients and may be a determinant factor to consider in whether to treat H. pylori infection in functional dyspepsia.


Dyspepsia Functional gastrointestinal disorders Helicobacter pylori Duodenitis 


Conflict of interest

No conflict of interest exists in relation to the submitted manuscript and there was no source of extra-institutional commercial funding.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Seyed Amir Mirbagheri
    • 1
  • Nasim Khajavirad
    • 1
    Email author
  • Nasser Rakhshani
    • 2
  • Mohammad Reza Ostovaneh
    • 1
  • Seyed Mahmood Eshagh Hoseini
    • 1
  • Vahid Hoseini
    • 3
  1. 1.Department of Internal Medicine, Amir-Alam HospitalSchool of Medicine, Tehran University of Medical SciencesTehranIran
  2. 2.Department of Pathology, Firoozgar HospitalSchool of Medicine, Tehran University of Medical SciencesTehranIran
  3. 3.Department of Internal Medicine, School of MedicineMazandaran University of Medical SciencesSariIran

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