Digestive Diseases and Sciences

, Volume 57, Issue 1, pp 196–203 | Cite as

The Relationship Between Arterial Stiffness and Nonalcoholic Fatty Liver Disease

  • Yong-Jae Lee
  • Jae-Yong Shim
  • Byung-Soo Moon
  • Youn-Ho Shin
  • Dong-Hyuk Jung
  • Jung-Hyun Lee
  • Hye-Ree Lee
Original Article

Abstract

Aim

Nonalcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease and some studies have documented its link with cardiovascular risk factors. This study aimed to investigate the association between arterial stiffness and NAFLD.

Methods

Among 1,442 health check-up subjects (955 men, 487 women), we examined the association between brachial-ankle pulse wave velocity (baPWV) as a measurement of arterial stiffness and the presence of NAFLD based on abdominal sonographic findings. Multivariate linear and logistic regression analyses were conducted to examine the independent association between baPWV and the presence of NAFLD in gender-specific manners.

Results

In multivariate regression analysis, NAFLD was found to be independently associated with baPWV in both men and women. Moreover, in multivariate logistic regression analysis, a graded independent relation was found between higher levels of baPWV and the prevalence risk of NAFLD. Odds ratios (95% CI) for the highest vs. the lowest quartile of baPWV were 1.85 (range, 1.13–2.62) in men and 3.32 (1.45–7.62) in women after adjusting for age, smoking status, regular exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, hypertension and diabetes.

Conclusion

Arterial stiffness was independently associated with the prevalence risk for NAFLD regardless of classical CVD risk factors.

Keywords

Arterial stiffness Pulse wave velocity Nonalcoholic fatty liver disease Cardiovascular disease Inflammation 

Abbreviations

NAFLD

Nonalcoholic fatty liver disease

CVD

Cardiovascular disease

BaPWV

Brachial-ankle pulse wave velocity

WBC

White blood cell

CVs

Coefficients of variations

HOMA-IR

Homeostasis model assessment of the insulin resistance index

IMT

Intima-media thickness

ROS

Reactive oxygen species

IL-6

Interleukin-6

TNF-α

Tumor necrosis factor-α

NO

Nitric oxide

PAI-1

Plasminogen activator inhibitor-1

Notes

Acknowledgments

The authors would like to thank Mr. Tim Gitzen for his help in editing the manuscript.

Conflict of interest

No competing financial interests exist.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yong-Jae Lee
    • 1
  • Jae-Yong Shim
    • 1
  • Byung-Soo Moon
    • 2
  • Youn-Ho Shin
    • 3
  • Dong-Hyuk Jung
    • 1
  • Jung-Hyun Lee
    • 4
  • Hye-Ree Lee
    • 1
  1. 1.Department of Family MedicineYonsei University College of MedicineSeoulKorea
  2. 2.Department of Internal MedicineYonsei University College of MedicineSeoulKorea
  3. 3.Department of PediatricsCHA University College of MedicineSeoulKorea
  4. 4.Department of Health Promotion CenterGangnam Severance Hospital, Yonsei University College of MedicineSeoulKorea

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