The Relationship Between Arterial Stiffness and Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease and some studies have documented its link with cardiovascular risk factors. This study aimed to investigate the association between arterial stiffness and NAFLD.
Among 1,442 health check-up subjects (955 men, 487 women), we examined the association between brachial-ankle pulse wave velocity (baPWV) as a measurement of arterial stiffness and the presence of NAFLD based on abdominal sonographic findings. Multivariate linear and logistic regression analyses were conducted to examine the independent association between baPWV and the presence of NAFLD in gender-specific manners.
In multivariate regression analysis, NAFLD was found to be independently associated with baPWV in both men and women. Moreover, in multivariate logistic regression analysis, a graded independent relation was found between higher levels of baPWV and the prevalence risk of NAFLD. Odds ratios (95% CI) for the highest vs. the lowest quartile of baPWV were 1.85 (range, 1.13–2.62) in men and 3.32 (1.45–7.62) in women after adjusting for age, smoking status, regular exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, hypertension and diabetes.
Arterial stiffness was independently associated with the prevalence risk for NAFLD regardless of classical CVD risk factors.
KeywordsArterial stiffness Pulse wave velocity Nonalcoholic fatty liver disease Cardiovascular disease Inflammation
Nonalcoholic fatty liver disease
Brachial-ankle pulse wave velocity
White blood cell
Coefficients of variations
Homeostasis model assessment of the insulin resistance index
Reactive oxygen species
Tumor necrosis factor-α
Plasminogen activator inhibitor-1
The authors would like to thank Mr. Tim Gitzen for his help in editing the manuscript.
Conflict of interest
No competing financial interests exist.
- 20.Kogiso T, Moriyoshi Y, Shimizu S, Nagahara H, Shiratori K. High-sensitivity C-reactive protein as a serum predictor of nonalcoholic fatty liver disease based on the Akaike information criterion scoring system in the general Japanese population. J Gastroenterol. 2009;44:313–321.PubMedCrossRefGoogle Scholar
- 22.Bahcecioglu IH, Yalniz M, Ataseven H, et al. Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients in nonalcoholic steatohepatitis. Heaptogastroenterology. 2005;52:1549–1553.Google Scholar