Digestive Diseases and Sciences

, Volume 56, Issue 7, pp 2202–2204 | Cite as

Isolated Russell Body Duodenitis

  • N. M. SavageEmail author
  • T. Fortson
  • M. Schubert
  • S. Chamberlain
  • J. Lee
  • P. Ramalingam
Case Report


Under the influence of an antigen, plasma cells produce immunoglobulins, which appear as eosinophilic globules on light microscopy. Sometimes, one or more of the cisterns of rough endoplasmic reticulum in plasma cells may become distended with these immunoglobulin-containing inclusions, termed Russell bodies, which were first described in 1890 by W. Russell [1]. These bodies are probably a result of disturbed secretion [2]. Mott cells are plasma cells containing multiple Russell bodies. Mott cells can be found in numerous settings, including: multiple myeloma, indolent lymphomas, and in the setting of chronic inflammation. Therefore, their presence alone is not indicative of malignancy.

Russell body gastritis (RBG), a localized collection of polyclonal Russell bodies in the stomach, is an uncommon, yet well-reported entity that is often associated with Helicobacter pylori infection [3, 4]. It was first described in 1998 in Japan by Tazawa and Tsutsumi [3]. They reported a...


Russell body Helicobacter pylori Gastritis Duodenitis 


Conflicts of interest

There are no conflicts to disclose.


  1. 1.
    Russell W. An address on a characteristic organism of cancer. Br Med J. 1890;2:1356–1360.PubMedCrossRefGoogle Scholar
  2. 2.
    Hsu SM, Hsu PL, McMillan PN, et al. Russell bodies: a light and electron microscopic immunoperoxidase study. Am J Clin Pathol. 1982;77:26–31.PubMedGoogle Scholar
  3. 3.
    Tazawa K, Tsutsumi Y. Localized accumulation of Russell body-containing plasma cells in gastric mucosa with Helicobacter pylori infection: ‘Russell body gastritis’. Pathology Int. 1998;48:242–244.CrossRefGoogle Scholar
  4. 4.
    Erbersdobler A, Petri S, Lock G. Russell body gastritis: an unusual, tumor-like lesion of the gastric mucosa. Arch Pathol Lab Med. 2004;128:915–917.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • N. M. Savage
    • 1
    Email author
  • T. Fortson
    • 2
  • M. Schubert
    • 3
  • S. Chamberlain
    • 3
  • J. Lee
    • 1
    • 4
  • P. Ramalingam
    • 1
  1. 1.Department of Pathology (PGY4)Medical College of GeorgiaAugustaUSA
  2. 2.School of MedicineMedical College of GeorgiaAugustaUSA
  3. 3.Department of Medicine, Section of Gastroenterology/HepatologyMedical College of GeorgiaAugustaUSA
  4. 4.Department of PathologyCharlie Norwood VA Medical CenterAugustaUSA

Personalised recommendations