Digestive Diseases and Sciences

, Volume 56, Issue 6, pp 1749–1756 | Cite as

Early Signet Ring Cell Gastric Cancer

  • Cheng-Tang Chiu
  • Chia-Jung Kuo
  • Ta-Sen YehEmail author
  • Jun-Te Hsu
  • Keng-Hao Liu
  • Chun-Nan Yeh
  • Tsann-Long Hwang
  • Yi-Yin Jan
  • Chun-Jung Lin
Original Article



Signet ring cell carcinoma (SRC) is defined as a histological entity. The clinicopathological characteristics and prognosis of gastric SRC remain controversial.


From 1994 to 2006, 2,439 patients with gastric carcinoma who underwent gastrectomy were enrolled. Of these, 505 patients (20.7%) had SRC and were compared to 1,934 patients with other histological types.


Twenty-nine percent of patients in the SRC group (n = 149) had early gastric cancer, with tumor invasion limited to the mucosa or submucosa, compared to 22.2% of patients in the non-SRC group (n = 430). The proportion of regional LN metastases was 10.7 and 16.0% in early SRC and early non-SRC, respectively, (p = 0.115). The 5-year survival rates for patients with early SRC were better than those for patients with early non-SRC (96.1 vs. 89.6%, p = 0.01).


Early gastric SRC has favorable prognosis. There is no significant difference in terms of LN metastasis between SRC histologic type and other histological types. Less-invasive strategies may be acceptable in selected patients with early gastric SRC.


Gastric cancer Signet ring cell carcinoma Histology Prognosis 



The authors thank Shu-Fang Hwang at the Departments of Surgery of Chang Gung Memorial Hospital for helpful data analysis.

Conflict of interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Cheng-Tang Chiu
    • 1
  • Chia-Jung Kuo
    • 1
  • Ta-Sen Yeh
    • 2
    Email author
  • Jun-Te Hsu
    • 2
  • Keng-Hao Liu
    • 2
  • Chun-Nan Yeh
    • 2
  • Tsann-Long Hwang
    • 2
  • Yi-Yin Jan
    • 2
  • Chun-Jung Lin
    • 1
  1. 1.Department of Gastroenetrology and Hepatology, Chang Gung Memorial HospitalChang Gung UniversityTaoyuanTaiwan
  2. 2.Department of Surgery, Chang Gung Memorial HospitalChang Gung UniversityTaoyuanTaiwan

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