Digestive Diseases and Sciences

, Volume 56, Issue 5, pp 1420–1426

Obese Patients Have Stronger Peristalsis and Increased Acid Exposure in the Esophagus

  • Fernando Fornari
  • Sidia M. Callegari-Jacques
  • Roberto Oliveira Dantas
  • Ana Lúcia Scarsi
  • Liana Ortiz Ruas
  • Sérgio Gabriel Silva de Barros
Original Article

DOI: 10.1007/s10620-010-1454-4

Cite this article as:
Fornari, F., Callegari-Jacques, S.M., Dantas, R.O. et al. Dig Dis Sci (2011) 56: 1420. doi:10.1007/s10620-010-1454-4
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Abstract

Background

Obesity is a risk factor for GERD and a potential modulator of esophageal motility.

Aim

To assess whether obese patients differ from non-obese patients in terms of esophageal motility and reflux.

Methods

Patients (n = 332) were categorized in GERD and controls after clinical assessment, esophageal manometry, and pH monitoring. Non-obese (BMI 16–29.9) and obese (BMI 30–68) were compared in regard of distal esophageal amplitude (DEA), LES pressure (LESP), manometric diagnosis, and esophageal acid exposure (EAE).

Results

Obese showed higher DEA in both controls (122 ± 53 vs. 97 ± 36 mmHg, p = 0.041) and GERD patients (109 ± 38 vs. 94 ± 46 mmHg, p < 0.001), higher LESP in GERD patients (20.5 ± 10.6 vs. 18.2 ± 10.6 mmHg, p = 0.049), higher frequency of nutcracker esophagus in controls (30 vs. 0%, p = 0.001), lower frequency of ineffective motility in GERD patients (6 vs. 20%, p = 0.001), and higher EAE in both controls [total EAE: 1.6% (0.7–5.1) vs. 0.9% (0.2–2.4), p = 0.027] and GERD patients [upright EAE: 6.5% (3.8–11.1) vs. 5.2% (1.5–10.6), p = 0.048]. Multiple linear regression showed that BMI was associated either with EAE (p < 0.001), DEA (p = 0.006), or LESP (in men, p = 0.007).

Conclusions

Obese patients differed from non-obese in terms of esophageal motility and reflux, regardless of the presence of GERD. Obese patients showed stronger peristalsis and increased acid exposure in the esophagus.

Keywords

Body mass index Esophageal motility disorders Gastroesophageal reflux disease Obesity 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Fernando Fornari
    • 1
    • 2
    • 5
  • Sidia M. Callegari-Jacques
    • 3
  • Roberto Oliveira Dantas
    • 4
  • Ana Lúcia Scarsi
    • 1
  • Liana Ortiz Ruas
    • 1
  • Sérgio Gabriel Silva de Barros
    • 5
  1. 1.Faculdade de MedicinaUniversidade de Passo FundoPasso Fundo-RSBrazil
  2. 2.ENDOPASSOPasso Fundo-RSBrazil
  3. 3.Departamento de Estatística e Programa de Pós-Graduação em Genética e Biologia MolecularUniversidade Federal do Rio Grande do Sul (UFRGS)Porto Alegre-RSBrazil
  4. 4.Departamento de Medicina, Faculdade de Medicina de Ribeirão PretoUniversidade de São PauloRibeirão Preto-SPBrazil
  5. 5.Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de MedicinaUFRGSPorto Alegre-RSBrazil

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