Digestive Diseases and Sciences

, Volume 56, Issue 4, pp 1107–1111 | Cite as

Adult Patients with Eosinophilic Esophagitis Do Not Show an Increased Frequency of the HLA-DQ2/DQ8 Genotypes Predisposing to Celiac Disease

  • Alfredo J. Lucendo
  • Ángel Arias
  • Isabel Pérez-Martínez
  • Antonio López-Vázquez
  • Jesús Ontañón-Rodríguez
  • Sonia González-Castillo
  • Livia C. De Rezende
  • Luis Rodrigo
Original Article

Abstract

Background

Recent articles have described patients that share eosinophilic esophagitis (EoE) and celiac disease (CD) suggesting a true relationship between both diseases.

Aims

The purpose of this study was to investigate whether HLA DQ2 and DQ8 predisposing to CD are increased in adult patients with EoE.

Methods

HLA alleles conferring risk for CD was assessed in 75 adult EoE patients attended at two hospitals located in different Spanish regions over the past 2 years. We compared the frequencies to the registered data of 421 healthy kidney and bone marrow donors from our hospitals for the following alleles: (a) DR3-DQ2 haplotype; (b) the combination of DR3-DQ2 and DR4-DQ8; (c) DR4-DQ8 haplotype; (d) the simultaneous presence of the DR5-DQ7 and DR7-DQ2 haplotypes; and lastly (e) any combination of haplotypes not conferring risk for the development of CD.

Results

The HLA DQ2 and DQ8 alleles were analyzed in 58 adult EoE patients from hospital #1 and in 20 patients from hospital #2, and they were compared to recorded HLA genotyping data from 298 and 123 healthy donors, respectively. No differences were found between the distribution of the HLA frequencies of the patients and controls at both hospitals and the data could be combined. EoE patients did not show increased frequencies of DQ2 and DQ8 alleles compared to controls.

Conclusions

Our work does not allow us to establish a common genetic basis for EoE and CD because an increased frequency of the HLA DQ2 and DQ8 alleles predisposing to CD was not observed in adult EoE patients compared to controls.

Keywords

Eosinophilic esophagitis Celiac disease HLA antigens DQ2 genotype DQ8 genotype 

Notes

Acknowledgments

We would like to thank Dr Jose María Tenias Burillo for providing us with his methodological support. This work was funded by a grant (FISCAM AN-2008/21) awarded to Alfredo J. Lucendo.

Conflict of interests

None.

References

  1. 1.
    Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–1363.PubMedCrossRefGoogle Scholar
  2. 2.
    Lucendo AJ, Lucendo B. An update on the immunopathogenesis of eosinophilic esophagitis. Expert Rev Gastroenterol Hepatol. 2010;4:141–148.PubMedCrossRefGoogle Scholar
  3. 3.
    Trier JS. Celiac sprue. N Engl J Med. 1991;325:1709–1719.PubMedCrossRefGoogle Scholar
  4. 4.
    Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology. 1992;102:330–354.PubMedGoogle Scholar
  5. 5.
    Rewers M. Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology. 2005;128:S47–S51.PubMedCrossRefGoogle Scholar
  6. 6.
    Thorsby E, Lie BA. HLA associated genetic predisposition to autoimmune diseases: genes involved and possible mechanisms. Transpl Immunol. 2005;14:175–182.PubMedCrossRefGoogle Scholar
  7. 7.
    Sollid LM, Markussen G, Ek J, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med. 1989;169:345–350.PubMedCrossRefGoogle Scholar
  8. 8.
    Kagalwalla AF, Shah A, Ritz S, et al. Cow’s milk protein—induced eosinophilic esophagitis in a child with gluten-sensitive enteropathy. J Pediatr Gastroenterol Nutr. 2007;44:386–388.PubMedCrossRefGoogle Scholar
  9. 9.
    Verzegnassi F, Bua J, De Angelis P, et al. Eosinophilic oesophagitis and coeliac disease: is it just a casual association? Gut. 2007;56:1029–1030.PubMedCrossRefGoogle Scholar
  10. 10.
    Quaglietta L, Coccorullo P, Miele E, et al. Eosinophilic oesophagitis and coeliac disease: is there an association? Aliment Pharmacol Ther. 2007;26:487–493.PubMedCrossRefGoogle Scholar
  11. 11.
    Leslie C, Mews C, Charles A, et al. Celiac disease and eosinophilic esophagitis: a true association. J Pediatr Gastroenterol Nutr. 2010;50:397–399.PubMedGoogle Scholar
  12. 12.
    Lipschitz B. Eosinophilic oesophagitis: association with HLA-DQ2 and HLA-DQ8. Gastroenterology. 2007;132:A282.Google Scholar
  13. 13.
    Barker JM, Liu E. Celiac disease: pathophysiology, clinical manifestations and associated autoimmune conditions. Adv Pediatr. 2008;55:349–365.PubMedCrossRefGoogle Scholar
  14. 14.
    Green PH, Jabri B. Coeliac disease. Lancet. 2003;362:383–391.PubMedCrossRefGoogle Scholar
  15. 15.
    Rodrigo L. Celiac disease. World J Gastroenterol. 2006;12:6585–6593.PubMedGoogle Scholar
  16. 16.
    Martín-Muñoz MF, Lucendo AJ, Navarro M, et al. Food allergy and eosinophilic esophagitis: two cases studies. Digestion. 2006;74:49–54.PubMedCrossRefGoogle Scholar
  17. 17.
    Straumann A, Simon HU. Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Inmunol. 2005;115:418–419.CrossRefGoogle Scholar
  18. 18.
    Patel SM, Falchuk KR. Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005;61:165–167.PubMedCrossRefGoogle Scholar
  19. 19.
    Weller PF. The immunobiology of eosinophils. N Engl J Med. 1991;324:1110–1118.PubMedCrossRefGoogle Scholar
  20. 20.
    Collins MH, Blanchard C, Albonia JP, et al. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Ciln Gastroenterol Hepatol. 2008;6:621–629.CrossRefGoogle Scholar
  21. 21.
    Kapel RC, Miller JK, Torres C, et al. Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. Gastroenterology. 2008;134:1316–1321.PubMedCrossRefGoogle Scholar
  22. 22.
    Katzka DA. Demographic data and symptoms of eosinophilic esophagitis in adults. Gastrointestinal Endosc Clin North Am. 2008;18:25–32.CrossRefGoogle Scholar
  23. 23.
    Soma J, Brown-Whitehorn TA, Spergel JM. Association of eosinophilic gastrointestinal disorders with other atopic disorders. Immunol Allergy Clin N Am. 2009;29:85–97.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Alfredo J. Lucendo
    • 1
  • Ángel Arias
    • 2
  • Isabel Pérez-Martínez
    • 3
  • Antonio López-Vázquez
    • 4
  • Jesús Ontañón-Rodríguez
    • 5
  • Sonia González-Castillo
    • 1
  • Livia C. De Rezende
    • 1
  • Luis Rodrigo
    • 3
  1. 1.Department of GastroenterologyHospital General de TomellosoTomelloso, Ciudad RealSpain
  2. 2.Research UnitComplejo Hospitalario La Mancha CentroAlcázar de San JuanSpain
  3. 3.Department of GastroenterologyHospital Central de AsturiasOviedoSpain
  4. 4.Department of ImmunologyHospital Central de AsturiasOviedoSpain
  5. 5.Department of ImmunologyHospital General Universitario de AlbaceteAlbaceteSpain

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