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Digestive Diseases and Sciences

, Volume 55, Issue 12, pp 3561–3567 | Cite as

Portal Hypertensive Gastropathy: Correlation with Portal Hypertension and Prognosis in Cirrhosis

  • Moon Young Kim
  • Hoon Choi
  • Soon Koo Baik
  • Chang Jin Yea
  • Chan Sik Won
  • Jong Won Byun
  • So Yeon Park
  • Yong Hwan Kwon
  • Jae Woo Kim
  • Hyun Soo Kim
  • Sang Ok Kwon
  • Young Ju Kim
  • Seung Hwan Cha
  • Sei Jin Chang
Original Article

Abstract

Background

Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis.

Methods

The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child–Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated.

Results

The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048–1.269) showed a significantly high relative risk of mortality, and in the Kaplan–Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030).

Conclusions

PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.

Keywords

Portal hypertensive gastropathy Portal hypertension Prognosis Cirrhosis 

Abbreviations

PHG

Portal hypertensive gastropathy

HVPG

Hepatic venous pressure gradient

MELD

Model for end-stage liver disease

Notes

Acknowledgments

This work was supported by a grant (no. A050021) from the Ministry for Health, Welfare, and Family Affairs, Republic of Korea.

Conflicts of interest statement

None to declare.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Moon Young Kim
    • 1
  • Hoon Choi
    • 1
  • Soon Koo Baik
    • 1
    • 4
  • Chang Jin Yea
    • 1
  • Chan Sik Won
    • 1
  • Jong Won Byun
    • 1
  • So Yeon Park
    • 1
  • Yong Hwan Kwon
    • 1
  • Jae Woo Kim
    • 1
  • Hyun Soo Kim
    • 1
  • Sang Ok Kwon
    • 1
  • Young Ju Kim
    • 2
  • Seung Hwan Cha
    • 2
  • Sei Jin Chang
    • 3
  1. 1.Department of Internal Medicine and Institute of Basic Medical ScienceYonsei University, Wonju College of MedicineWonjuSouth Korea
  2. 2.Department of RadiologyYonsei University, Wonju College of MedicineWonjuSouth Korea
  3. 3.Department of Preventive MedicineYonsei University, Wonju College of MedicineWonjuSouth Korea
  4. 4.Department of Internal Medicine and Institute of Lifelong HealthYonsei University, Wonju College of MedicineWonjuSouth Korea

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