Digestive Diseases and Sciences

, Volume 55, Issue 8, pp 2283–2287

The Effect of a Meal and Water Loading on Heart Rate Variability in Children with Functional Dyspepsia

  • Craig A. Friesen
  • Zhiyue Lin
  • Jennifer V. Schurman
  • Linda Andre
  • Richard W. McCallum
Original Article

DOI: 10.1007/s10620-009-1027-6

Cite this article as:
Friesen, C.A., Lin, Z., Schurman, J.V. et al. Dig Dis Sci (2010) 55: 2283. doi:10.1007/s10620-009-1027-6

Abstract

Background

Alteration in autonomic function has been implicated as a possible pathophysiologic mechanism in functional dyspepsia (FD) in adults.

Methods

This was a two-part study. For the first part of the study, nine children with FD and 28 controls underwent heart rate variability (HRV) analysis for 30 min baseline and for 60 min following a test meal. For the second part of the study, eight children with FD and 26 controls underwent HRV analysis for 30 min baseline and for 60 min following rapid water loading. HRV analysis yielded measures for power in the high frequency (HF) band (vagal activity), power in the low frequency (LF) band (mainly sympathetic activity), and LF/HF (sympathovagal balance).

Results

HRV parameters did not differ between FD patients and controls in either baseline period or following water loading. Following the meal, HF was higher and LF and LF/HF were lower in FD patients as compared to controls. Baseline LF/HF was positively correlated with the water load volume in controls and negatively correlated with the water load volume in FD patients.

Conclusion

FD in children is associated with an abnormal autonomic response best demonstrated following a meal. The relationship between baseline sympathovagal balance and water load volume in FD patients is distinctly different from the relationship in control children.

Keywords

Functional dyspepsia Heart rate variability Autonomic nervous system Water loading 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Craig A. Friesen
    • 1
  • Zhiyue Lin
    • 2
  • Jennifer V. Schurman
    • 3
  • Linda Andre
    • 1
  • Richard W. McCallum
    • 2
  1. 1.Section of GastroenterologyThe Children’s Mercy Hospital and ClinicsKansas CityUSA
  2. 2.Department of MedicineUniversity of Kansas Medical CenterKansas CityUSA
  3. 3.Section of Developmental and Behavioral SciencesThe Children’s Mercy Hospital and ClinicsKansas CityUSA

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