The Development of Autoimmune Hepatitis and Primary Biliary Cirrhosis Overlap Syndrome During the Course of Connective Tissue Diseases: Report of Three Cases and Review of the Literature
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The term hepatic overlap syndrome is used to describe variant forms of autoimmune hepatitis (AIH) that present characteristics of AIH and primary biliary cirrhosis (PBS) or primary sclerosing cholangitis (PSC). It is still unclear whether these overlap syndromes are different entities or they are only variants of major autoimmune hepatopathies, and they do not have codified definitions [1, 2, 3]. Patients with overlap syndrome present with both cholestatic and hepatitic profiles, either simultaneously or consecutively. AIH–PBC is the most common form, affecting almost 10% of patients with AIH or PBC [2, 3, 4]. Liver involvement in patients with connective tissue diseases (CTD) is an uncommon condition. Hepatotoxic drugs, coincident viral hepatitis and development of autoimmune hepatic diseases have been implicated as the main causes of liver diseases in patients with connective tissue diseases [5, 6, 7]. We present here the development of AIH–PBC overlap syndrome in three...
KeywordsConnective tissue disease Autoimmune hepatitis Primary biliary cirrhosis Overlap syndrome
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