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Digestive Diseases and Sciences

, Volume 55, Issue 5, pp 1364–1375 | Cite as

The Correlation of Endoscopic and Histological Diagnosis of Gastric Atrophy

  • Alisher Eshmuratov
  • Jong Chun Nah
  • Nayoung KimEmail author
  • Hye Seung Lee
  • Hee Eun Lee
  • Byoung Hwan Lee
  • Min Sik Uhm
  • Young Soo Park
  • Dong Ho Lee
  • Hyun Chae Jung
  • In Sung Song
Original Article

Abstract

Purpose

Gastric atrophy is a premalignant condition. The aim of this study was to evaluate the correlation between histological and endoscopic findings of atrophy, and to analyze the affecting factors.

Methods

Atrophy was graded by endoscopy, and biopsy was performed in the antrum and body for the diagnosis of atrophy according to the Sydney system in the 1,330 subjects.

Results

Both endoscopic and histological atrophy increased in proportion to age (P < 0.001). The prevalence of endoscopic atrophy was significantly lower than that of histological atrophy especially below 50 years of age. The sensitivity and specificity of endoscopy for the diagnosis of atrophy based on histological diagnosis of atrophy were 61.5 and 57.7% in the antrum, and were 46.8 and 76.4% in the body of the stomach. Multivariate analysis showed that an age <50 (OR 0.38, 95% CI 0.25–0.61) and a PG I/II ratio >3 (OR 0.50, 95% CI 0.35–0.71) in the antrum, and an age < 50 (OR 0.43, 95% CI 0.19–1.00) and a CRP > 5 mg/dl (OR 0.53, 95% CI 0.30–0.94) decreased the sensitivity of the endoscopic diagnosis of atrophy in the body.

Conclusions

A high index of suspicion of gastric atrophy is important in the young age group, and confirmation of the diagnosis by histology is necessary.

Keywords

Stomach Atrophy Endoscopy Histology 

Notes

Conflict of Interest or Financial Arrangement

No author has conflicts of interest or financial arrangements that could potentially influence the described research.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Alisher Eshmuratov
    • 1
  • Jong Chun Nah
    • 1
  • Nayoung Kim
    • 1
    • 3
    Email author
  • Hye Seung Lee
    • 2
  • Hee Eun Lee
    • 2
  • Byoung Hwan Lee
    • 1
  • Min Sik Uhm
    • 1
  • Young Soo Park
    • 1
    • 3
  • Dong Ho Lee
    • 1
    • 3
  • Hyun Chae Jung
    • 3
  • In Sung Song
    • 3
  1. 1.Department of Internal MedicineSeoul National University Bundang HospitalBundang-gu, SeongnamSouth Korea
  2. 2.Department of PathologySeoul National University Bundang HospitalSeoungnamKorea
  3. 3.Department of Internal Medicine and Liver Research InstituteSeoul National University College of MedicineSeoulKorea

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