Polycystic Ovary Syndrome Is Associated with an Increased Prevalence of Irritable Bowel Syndrome
- 448 Downloads
Polycystic ovary syndrome (PCOS) affects 5–10% of reproductive-aged women. Irritable bowel syndrome (IBS) is a chronic intestinal disorder that affects up to 20% of adults, more often women. We evaluate if there is a relationship between these common conditions.
Polycystic ovary syndrome and control subjects were prospectively recruited. A questionnaire was given to determine their gastrointestinal symptoms. Body mass index (BMI) and percent body fat were also calculated.
About 65 female subjects completed the study. Among the 36 PCOS patients, 15 subjects (42%) had IBS, compared to 3 subjects (10%) among controls (p < 0.01). Control subjects were leaner (BMI: 27.5 ± 1.1 vs. 31.4 ± 1.2 kg/m2, p < 0.05) than PCOS patients. Among women with PCOS, those with IBS had a higher BMI (32.9 ± 2.0 kg/m2) compared to those with PCOS but no IBS (30.3 ± 1.6 kg/m2) and controls (27.5 ± 1.1 kg/m2; p < 0.05). This difference was true even after correcting for BMI and age (p < 0.01).
Women with PCOS have a higher prevalence of IBS compared to healthy controls. When IBS is present with PCOS, a higher BMI and percent body fat is seen compared to PCOS alone.
KeywordsPolycystic ovary syndrome Irritable bowel syndrome
- 13.El-Serag HB. Impact of irritable bowel syndrome: prevalence and effect on health-related quality of life. Rev Gastroenterol Disord. 2003;3(Suppl 2):S3–11.Google Scholar
- 22.Zawadzki JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome. Boston: Blackwell; 1992:377–384.Google Scholar
- 24.Drossman DA, Richter JE, Talley NJ, et al., eds. Functional gastrointestinal disorders: diagnosis, pathophysiology, and treatment: a multinational consensus. Boston: Little Brown; 1994.Google Scholar
- 30.Giamberardino M. Sex-related and hormonal modulation of visceral pain. In: Fillingim R, ed. Sex gender and pain, vol. 17. Seattle: IASP; 2000.Google Scholar