Digestive Diseases and Sciences

, Volume 55, Issue 4, pp 1182–1185 | Cite as

Acute Hepatitis Due to Epstein–Barr Virus in an Immunocompetent Patient

  • Neha Pagidipati
  • Keith L. ObsteinEmail author
  • Rachel Rucker-Schmidt
  • Robert D. Odze
  • Christopher C. Thompson


Epstein–Barr virus (EBV) infects over 90% of humans and persists throughout life. Typically, EBV infection in infants and children is asymptomatic or is manifest by nonspecific symptoms [1]. In adolescents and adults, EBV infection can result in infectious mononucleosis, which presents with the triad of fever, lymphadenopathy, and pharyngitis in over 50% of cases. Though often unrecognized, EBV infection can cause mild elevation in serum aminotransferase levels in 90% of patients, with clinically significant EBV-induced liver damage occurring only rarely in immunocompetent individuals [2, 3]. We present a 21-year-old female diagnosed with acute clinically significant EBV-induced hepatitis that was confirmed by pathology and serologic studies. We also review the literature on the clinical presentation, diagnostic criteria, histopathological characteristics, and management of EBV hepatitis.

Case Report

A 21-year-old Caucasian female with cognitive delay was brought to the...


Epstein–Barr virus Hepatitis Serology PCR IsH 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Neha Pagidipati
    • 1
  • Keith L. Obstein
    • 1
    • 2
    • 4
    Email author
  • Rachel Rucker-Schmidt
    • 3
  • Robert D. Odze
    • 3
  • Christopher C. Thompson
    • 1
    • 2
  1. 1.Department of MedicineBrigham and Women’s HospitalBostonUSA
  2. 2.Division of GastroenterologyBrigham and Women’s HospitalBostonUSA
  3. 3.Department of PathologyBrigham and Women’s HospitalBostonUSA
  4. 4.Department of Medicine, Division of GastroenterologyBrigham and Women’s HospitalBostonUSA

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