Digestive Diseases and Sciences

, Volume 54, Issue 12, pp 2736–2741 | Cite as

A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

  • Hamed N. Khan
  • Margaret Harrison
  • Eryl E. Bassett
  • Tom Bates
Original Article


The purpose of this study was to examine a previous increase in male gallstone disease and to consider the burden of gallstones in a necropsy study with matched controls over a decade. Gallstone prevalence in 5,050 males fell from 20.2% to 19.1% (P = 0.022) and in 4,125 females fell from 30.4% to 29.0% (P = 0.03). Female gallstone subjects had a higher BMI than controls 24.5 vs. 23.3 (P < 0.01), but males did not. Gallstones were twice as common in diabetics, but not with coronary heart disease (CHD). A third of elderly patients of both sexes had gallstones, but cholecystectomy was more common in females, 17:10%. Gallstone-related mortality was 0.7%. The prevalence of gallstones fell slightly. The association between gallstones and diabetes was confirmed, but not for CHD, and for BMI this was confined to females. Gallstones are very common in the elderly, but most are unoperated and seldom cause death.


Case control Cholecystectomy Coronary heart disease Diabetes Gallstones Necropsy Obesity Prevalence 



We thank Susan Bendall for data analysis and S. Paulvannan for data input. We thank the pathologists Dr M. King, Dr N. Padley and Dr C. Lawson.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Hamed N. Khan
    • 1
  • Margaret Harrison
    • 2
  • Eryl E. Bassett
    • 3
  • Tom Bates
    • 2
    • 4
  1. 1.The Breast DepartmentRoyal Hallamshire HospitalSheffieldUK
  2. 2.Department of SurgeryWilliam Harvey HospitalAshford, KentUK
  3. 3.Institute of Mathematics & StatisticsUniversity of KentCanterburyUK
  4. 4.Ashford, KentUK

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