Digestive Diseases and Sciences

, Volume 54, Issue 5, pp 1071–1078

Synbiotics Decrease the Incidence of Septic Complications in Patients with Severe SIRS: A Preliminary Report

  • Kentaro Shimizu
  • Hiroshi Ogura
  • Miki Goto
  • Takashi Asahara
  • Koji Nomoto
  • Masami Morotomi
  • Asako Matsushima
  • Osamu Tasaki
  • Kieko Fujita
  • Hideo Hosotsubo
  • Yasuyuki Kuwagata
  • Hiroshi Tanaka
  • Takeshi Shimazu
  • Hisashi Sugimoto
ORIGINAL ARTICLE

DOI: 10.1007/s10620-008-0460-2

Cite this article as:
Shimizu, K., Ogura, H., Goto, M. et al. Dig Dis Sci (2009) 54: 1071. doi:10.1007/s10620-008-0460-2

Abstract

The purpose of this study was to evaluate if synbiotic therapy can correct the deteriorated gut flora and environment in patients with severe systemic inflammatory response syndrome (SIRS). Twenty-nine SIRS patients, who fulfilled a serum C-reactive protein (CRP) level >10 mg/dl, received synbiotics (Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides) (S group) and were compared with previous observations in 26 patients without synbiotics (NS group). Analysis of fecal flora confirmed that patients in the S group had significantly greater levels of beneficial Bifidobacterium, Lactobacillus, and total organic acids (particularly short-chain fatty acids) than those in the NS group. The incidence of infectious complications such as enteritis, pneumonia, and bacteremia was significantly lower in the S group than in the NS group. Synbiotics maintain the gut flora and environment and decrease the incidence of septic complications in patients with severe SIRS. Further randomized controlled study is necessary to determine the effects of synbiotics.

Keywords

Gut Flora Short-chain fatty acid pH SIRS Synbiotics Probiotics 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Kentaro Shimizu
    • 1
  • Hiroshi Ogura
    • 1
  • Miki Goto
    • 1
  • Takashi Asahara
    • 2
  • Koji Nomoto
    • 2
  • Masami Morotomi
    • 2
  • Asako Matsushima
    • 1
  • Osamu Tasaki
    • 1
  • Kieko Fujita
    • 1
  • Hideo Hosotsubo
    • 1
  • Yasuyuki Kuwagata
    • 1
  • Hiroshi Tanaka
    • 1
  • Takeshi Shimazu
    • 1
  • Hisashi Sugimoto
    • 1
  1. 1.Department of Traumatology and Acute Critical MedicineOsaka University Graduate School of MedicineSuita CityJapan
  2. 2.Yakult Central Institute for Microbiological ResearchTokyoJapan

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