The Association Between the Survivin C-31G Polymorphism and Gastric Cancer Risk in a Chinese Population

  • Li Yang
  • Huaijun Zhu
  • Bo Zhou
  • Haijuan Gu
  • Hongli Yan
  • Naping Tang
  • Hanzhang Dong
  • Qingmin Sun
  • Rihong Cong
  • Guoyu Chen
  • Bin Wang
Original Article

Abstract

Introduction The C-31G polymorphism in the survivin promoter could de-represse the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect of the polymorphism on other cancers, including gastric cancer. Methods In this hospital-based, case–control study, we investigated the association between the survivin C-31G polymorphism and risk of gastric cancer in a Chinese population using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) protocols. Results No statistically significant association was observed between gastric cancer risk and the variant genotype (GG + GC). However, the variant genotype (GG + GC) was either associated with risk of distal gastric cancer (odds ratios = 0.50, 95% confidence interval = 0.30–0.83) or with risk of well-differentiated tumor (odds ratios = 0.46, 95% confidence interval = 0.22–0.97). Conclusion Our results demonstrate that the survivin C-31G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in a Chinese population.

Keywords

Survivin Polymorphism Gastric cancer Apoptosis 

Abbreviations

CI

Confidence interval

OR

Odds ratio

PCR

Polymerase chain reaction

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Li Yang
    • 1
  • Huaijun Zhu
    • 2
  • Bo Zhou
    • 3
  • Haijuan Gu
    • 3
  • Hongli Yan
    • 4
  • Naping Tang
    • 3
  • Hanzhang Dong
    • 1
  • Qingmin Sun
    • 3
  • Rihong Cong
    • 3
  • Guoyu Chen
    • 1
  • Bin Wang
    • 3
  1. 1.Department of General SurgeryFirst Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  2. 2.Department of PharmacyThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina
  3. 3.Department of Pharmacology, Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjingChina
  4. 4.Dongzhi Health Inspection BureauDongzhiChina

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