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The Relationship Between Updated Sydney System Score and LDL Cholesterol Levels in Patients Infected with Helicobacter pylori

  • Metin Kucukazman
  • Bunyamin YavuzEmail author
  • Muhammed Sacikara
  • Zeliha Asilturk
  • Naim Ata
  • Derun Taner Ertugrul
  • Ahmet Arif Yalcin
  • Ezgi Coskun Yenigun
  • Guler Kizilca
  • Heyecan Okten
  • Kadir Okhan Akin
  • Yasar Nazligul
Original Article

Abstract

Objectives Helicobacter pylori (H. pylori) chronically infects the human stomach and may cause extra-gastrointestinal diseases. The role of H. pylori in the pathogenesis of atherosclerosis and its effect on lipids remains controversial. The aim of this study was to examine lipid levels in patients with and without H. pylori infection. Methods A total of 244 consecutive patients who underwent esophagogastroduodenoscopy were included in this study. Patients receiving statin and fibrate therapy and diabetic patients were excluded. Biopsies from each individual were taken and analyzed for H. pylori detection using ultrastructural methods. Patients were divided into two groups: H. pylori (+) (group 1) and H. pylori (−) (group 2). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels were measured in all subjects. Results A total of 163 patients were included in group 1 and 81 patients were included in group 2. Frequency of H. pylori was 67% in the study population. Total cholesterol (204 ± 39 mg/dl versus 189 ± 42 mg/dl, respectively; P = 0.007) and LDL-C (128 ± 30 mg/dl versus 116 ± 32 mg/dl, respectively; P = 0.003) were significantly higher in group 1 than in group 2. Updated Sydney classification score showed a positive correlation with LDL-C (r = 0.333, P < 0.001) and TC (r = 0.288, P < 0.001) levels. Conclusion Increased levels of TC and LDL-C were found in patients infected with H. pylori, and updated Sydney System score showed a positive correlation with LDL-C and TC levels. These findings may explain why H. pylori infection is associated with increased risk of atherosclerosis.

Keywords

Helicobacter pylori LDL Total cholesterol Updated Sydney System Atherosclerosis 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Metin Kucukazman
    • 1
  • Bunyamin Yavuz
    • 2
    Email author
  • Muhammed Sacikara
    • 1
  • Zeliha Asilturk
    • 1
  • Naim Ata
    • 1
  • Derun Taner Ertugrul
    • 1
  • Ahmet Arif Yalcin
    • 2
  • Ezgi Coskun Yenigun
    • 1
  • Guler Kizilca
    • 1
  • Heyecan Okten
    • 3
  • Kadir Okhan Akin
    • 4
  • Yasar Nazligul
    • 1
  1. 1.Department of Internal MedicineKecioren Research HospitalAnkaraTurkey
  2. 2.Department of CardiologyKecioren Research HospitalAnkaraTurkey
  3. 3.Department of PathologyKecioren Research HospitalAnkaraTurkey
  4. 4.Department of BiochemistryKecioren Research HospitalAnkaraTurkey

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