Digestive Diseases and Sciences

, Volume 53, Issue 12, pp 3225–3233 | Cite as

The Expression of Hypoxia-Inducible Factor-1α in Hepatitis B Virus-Related Hepatocellular Carcinoma: Correlation with Patients’ Prognosis and Hepatitis B Virus X Protein

  • Huahong Xie
  • Jiugang Song
  • Kaige Liu
  • Hongzan Ji
  • Huiqin Shen
  • Shengjuan Hu
  • Guitao Yang
  • Yulei Du
  • Xue Zou
  • Haifeng Jin
  • Li Yan
  • Jie Liu
  • Daiming Fan
Original Paper

Abstract

Hypoxia inducible factor-1α (HIF-1α) was well correlated with carcinogenesis and tumor progression in many kinds of cancer. In this study, high expression of HIF-1α was found in 37 of the 72 (51.39%) tumor specimens, and significantly correlated with venous invasion and lymphonode invasion. Patients with high expression of HIF-1α had a significantly shorter overall survival rate and disease-free survival rate than those with low expression. Multivariate analysis showed high HIF-1α expression was a borderline independent factor of overall survival. HIF-1α expression was also found to be significantly correlated with the expression of hepatitis B virus X protein (HBx), and over-expressed HBx upregulated HIF-1α protein expression in vitro. These results suggested that HIF-1α, which was partially regulated by HBx, might be a prognostic marker of HBV-related HCC patients.

Keywords

Hypoxia inducible factor-1α Hepatitis B virus Hepatocellular carcinoma Prognosis Hepatitis B virus X protein 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Huahong Xie
    • 1
  • Jiugang Song
    • 1
  • Kaige Liu
    • 1
  • Hongzan Ji
    • 2
  • Huiqin Shen
    • 1
  • Shengjuan Hu
    • 1
  • Guitao Yang
    • 1
  • Yulei Du
    • 1
  • Xue Zou
    • 1
  • Haifeng Jin
    • 1
  • Li Yan
    • 1
  • Jie Liu
    • 1
  • Daiming Fan
    • 1
  1. 1.State Key Laboratory of Cancer Biology, Institute of Digestive DiseasesXijing Hospital, the Fourth Military Medical UniversityXi’anPeople’s Republic of China
  2. 2.Department of Geriatric GastroenterologyNanjing General Hospital of Nanjing Military Command of PLANanjingPeople’s Republic of China

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