Digestive Diseases and Sciences

, Volume 53, Issue 4, pp 972–976 | Cite as

Effect of a Gluten-free Diet on the Risk of Enteropathy-associated T-cell Lymphoma in Celiac Disease

  • Marco Silano
  • Umberto Volta
  • Alessandro De Vincenzi
  • Mariarita Dessì
  • Massimo De Vincenzi
  • The Collaborating Centers of the Italian Registry of the Complications of Coeliac Disease
Original Paper


Patients with celiac disease have an increased rate of enteropathy-associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9–12.2; P < 0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac diasese and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02–0.88; P < 0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X= 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.


Celiac disease Enteropathy-associated T-cell lymphoma Gluten-free diet 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Marco Silano
    • 1
  • Umberto Volta
    • 2
  • Alessandro De Vincenzi
    • 3
  • Mariarita Dessì
    • 4
  • Massimo De Vincenzi
    • 1
  • The Collaborating Centers of the Italian Registry of the Complications of Coeliac Disease
    • 5
  1. 1.Division of Food Science, Human Nutrition and HealthIstituto Superiore di SanitàRomeItaly
  2. 2.Department of Internal MedicineS. Orsola-Malpighi Hospital BolognaItaly
  3. 3.Fatebenefratelli Hospital RomeItaly
  4. 4.Department of Laboratory MedicineUniversity Hospital Tor Vergata RomeItaly
  5. 5.Istituto Superiore di SanitàRomeItaly

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