Autonomic Nervous System Function During Sleep Among Women with Irritable Bowel Syndrome
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This study compared heart-rate variability (HRV) indices of autonomic nervous system function during two nights of sleep between women with irritable bowel syndrome (IBS, n = 35) and healthy controls (n = 38), and among subgroups within the IBS sample based on predominant stool patterns. HRV measures were estimated in conjunction with polysomnographic sleep scoring to define sleep stage-specific autonomic indices. Overall, there were no differences in indicators of HRV between women with IBS and controls. However, within the IBS group, women with diarrhea-predominant IBS demonstrated significantly increased parasympathetic modulation and lower sympathetic/parasympathetic nervous system balance across sequential NREM periods and REM cycles compared to both constipation-predominant and alternating IBS subjects. These results suggest that differences in mean level of HRV between predominant bowel groups in IBS patients are large, and that this effect is consistent in the different sleep stages and at different times of night.
KeywordsHeart-rate variability Irritable bowel syndrome Sleep Autonomic nervous system
We would like to thank Drs. Roseanne Armitage and Robert F. Hoffmann at the University of Michigan-Ann Arbor Sleep and Chronophysiology Laboratory for sharing their NREMPGET program to identify and to partition NREM periods during sleep. We would also like to thank the women who volunteered for this study, which involved sleeping for several nights in a strange place covered by electrodes. We appreciated Dr. Marty Lentz’s willingness to be consulted on issues large and small related to sleep. Supported by grants from the NINR, NIH (NR01094 and P30 NR04001).
- 11.Drossman D, Corazziari E, Talley N, Thompson W, Whitehead W (2000) Rome II: the functional gastrointestinal disorders. Degnon, McLeanGoogle Scholar
- 14.American Academy of Sleep Medicine (1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 22:667–689Google Scholar
- 15.The Atlas Task Force (1993) Recording and scoring leg movements. The Atlas Task Force. Sleep 16:748–759Google Scholar
- 17.Klem G, Luders H, Jasper H, Elger C (1999) The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol 52:3–6Google Scholar
- 18.Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Brain Information Service/Brain Research Institute, University of California, Los AngelesGoogle Scholar
- 21.Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93:1043–1065Google Scholar
- 29.Derogatis L (1994) SCL-90R: administration, scoring and procedures manual. NCS Pearson, MinneapolisGoogle Scholar
- 31.Lazarus R, Folkman S (1996) Hassles and uplifts scales. Mind Garden, Palo AltoGoogle Scholar
- 34.Garrigues V, Mearin F, Badia X, Balboa A, Benavent J, Caballero A, Dominguez E, Diaz-Rubio M, Roset M, Figueras M, Cucala M (2007) Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study). Aliment Pharmacol Ther 25:323–332PubMedCrossRefGoogle Scholar