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Gastric Emptying is Altered with the Presence of Gastritis

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Abstract

Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori influences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge with H. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive 13C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.

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References

  1. Saslow S, Thumshirn M, Camilleri M, Locke G, Thomforde G, Burton D, Hanson R (1998) Influence of H. pylori infection on gastric motor and sensory function in asymptomatic volunteers. Dig Dis Sci 43:258–264

    Article  PubMed  CAS  Google Scholar 

  2. Testoni P, Bagnolo F, Masci E, Colombo E, Tittobello A (1993) Different interdigestive antroduodenal motility patterns in chronic antral gastritis with and without Helicobacter pylori infection. Dig Dis Sci 38:2255–2261

    Article  PubMed  CAS  Google Scholar 

  3. Chiloiro M, Russo F, Riezzo G, Leoci C, Clemente C, Catrina M, Di Leo A (2001) Effect of Helicobacter pylori infection on gastric emptying and gastroinestinal hormones in dyspeptic and healthy subjects. Dig Dis Sci 46:46–53

    Article  PubMed  CAS  Google Scholar 

  4. Duval-Araujo I, De Magal-Aes Queiroz D, Magnago A, Simal C, Marino VS, Carvalho S, Da Silva Machado L, Miranda D (2000) Increased gastric emptying induced by Helicobacter heilmannii type 1 infection in rats. J Med Microbiol 49:627–634

    PubMed  CAS  Google Scholar 

  5. Goh K, Paramsothy M, Azian M, Parasakthi N, Peh S, Bux S, Lo Y, Ong K (1997) Does Helicobacter pylori infection affect gastric emptying in patients with functional dyspepsia. J Gastroenterol Hepatol 12:790–794

    PubMed  CAS  Google Scholar 

  6. Konturek J, Stoll R, Menzel J, Konturek M, Konturek S, Domschke W (2001) Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients. Scand J Gastroenterol 36:241–246

    Article  PubMed  CAS  Google Scholar 

  7. Okumura T, Shoji E, Takahashi N, Wakebe H, Imagawa K, Kikuchi M, Kohgo Y (1998) Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats. Dig Dis Sci 43:90–94

    Article  PubMed  CAS  Google Scholar 

  8. Onuk M, Uslu H, Varoglu E (2001) Effects of eradication therapy on gastric emptying in patients with Helicobacter pylori-positive duodenal ulcers. J Int Med Res 29:178–180

    PubMed  CAS  Google Scholar 

  9. Perri F, Ghoos Y, Maes B, Geypens B, Ectors N, Geboes K, Hiele M, Rutgeerts P (1996) Gastric emptying and Helicobacter pylori infection in duodenal ulcer disease. Dig Dis Sci 41:462–468

    Article  PubMed  CAS  Google Scholar 

  10. Symonds E, Butler R, Omari T (2000) Assessment of gastric emptying in the mouse using the [13C]-octanoic acid breath test. Clin Exp Pharm Physiol 27:671–675

    Article  CAS  Google Scholar 

  11. Symonds E, Butler R, Omari T (2002) Noninvasive breath tests can detect alterations in gastric emptying in the mouse. Eur J Clin Invest 32:341–344

    Article  PubMed  CAS  Google Scholar 

  12. Lee A, O’Rourke J, De Ungria M, Robertson B, Daskalopoulos G, Dixon M (1997) A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterol 112:1386–1397

    Article  CAS  Google Scholar 

  13. Howarth G, Francis G, Cool J, Xu X, Byard R, Read L (1996) Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 126:2519–2530

    PubMed  CAS  Google Scholar 

  14. Desai K, Sato R, Schauble E, Barsh G, Kobilka B, Bernstein D (1997) Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. Am J Physiol 272:H1053–H1061

    PubMed  CAS  Google Scholar 

  15. Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, Vantrappen G (1993) Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterol 104:1640–1647

    CAS  Google Scholar 

  16. Symonds E (2003) Non-invasive assessment of gastrointestinal function using breath test technology: investigations in health and disease. In Physiology Department. Adelaide, The University of Adelaide

  17. Gledhill T, Leicester R, Addis B, Lightfoot N, Barnard J, Viney N, Darkin D, Hunt RH (1985) Epidemic hypochlorhydria. BMJ (Clin Res Ed) 290:1383–1386

    Article  CAS  Google Scholar 

  18. Mohammadi M, Redline R, Nedrud J, Czinn S (1996) Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred and congenic mouse strains. Infect Immun 64:238–245

    PubMed  CAS  Google Scholar 

  19. Domínguez-Muñoz J, Malfertheiner P (2001) Effect of Helicobacter pylori infection on gastrointestinal motility, pancreatic secretion and hormone release in asymptomatic humans. Scand J Gastroenterol 36:1141–1147

    Article  PubMed  Google Scholar 

  20. Murakami K, Fujioka T, Shiota K, Ito A, Fujiyama K, Kodama R, Kawasaki Y, Kubota T, Nasu M (1995) Influence of Helicobacter pylori infection and the effects of its eradication on gastric emptying in non-ulcerative dyspepsia. Eur J Gastroenterol Hepatol 7:S93–S97

    PubMed  Google Scholar 

  21. Debas H, Farooq O, Grossman M (1975) Inhibition of gastric emptying is a physiological action of cholecystokinin. Gastroenterol 68:1211–1217

    CAS  Google Scholar 

  22. Moran T, Wirth J, Schwartz G, McHugh P (1999) Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying. Am J Physiol 276:R997–R1002

    PubMed  CAS  Google Scholar 

  23. Lee A (1995) Helicobacter infection in laboratory animals: a model for gastric neoplasias? Ann Med 27:575–582

    Article  PubMed  CAS  Google Scholar 

  24. Maddern G, Horowitz M, Hetzel D, Jamieson G (1985) Altered solid and liquid gastric emptying in patients with duodenal ulcer disease. Gut 26:689–693

    Article  PubMed  CAS  Google Scholar 

  25. Paraskevopoulos J, Houghton L, Eyre-Brooke I, Johnson A, Read N (1988) Effect of composition of gastric contents on resistance to emptying of liquids from stomach in humans. Dig Dis Sci 33:914–918

    Article  PubMed  CAS  Google Scholar 

  26. Lee J, Camilleri M, Zinsmeister A, Burton D, Kost L, Klein P (2000) A valid, accurate, office based non-radioactive test for gastric emptying of solids. Gut 46:768–773

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Gastroenterology Unit, Children, Youth and Women’s Health Service, 72 King William Road, North Adelaide, 5006, South Australia

    Erin L. Symonds, Cuong D. Tran, Ross N. Butler & Taher I. Omari

  2. Department of Paediatrics, The University of Adelaide, Adelaide, South Australia

    Ross N. Butler & Taher I. Omari

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  1. Erin L. Symonds
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  2. Cuong D. Tran
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  3. Ross N. Butler
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  4. Taher I. Omari
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Correspondence to Erin L. Symonds.

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Symonds, E.L., Tran, C.D., Butler, R.N. et al. Gastric Emptying is Altered with the Presence of Gastritis. Dig Dis Sci 53, 636–641 (2008). https://doi.org/10.1007/s10620-007-9928-8

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  • DOI: https://doi.org/10.1007/s10620-007-9928-8

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